Chemical exchange saturation transfer fingerprinting for exchange rate quantification.
Chemical exchange saturation transfer fingerprinting for exchange rate quantification.
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DOI：
10.1002/mrm.27363
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发表时间：
2018-10
影响因子：
3.3
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Zhou Z;Han P;Zhou B;Christodoulou AG;Shaw JL;Deng Z;Li D
人们越来越有兴趣使用CEST来确定汇率，以提供pH值信息。然而，当前的CEST量化方法需要冗长的扫描时间并且不解决磁化转移效应。本工作的目的是将磁共振指纹（MRF）概念应用于CEST，以实现更有效和准确的汇率量化。所提出的CEST指纹识别方法使用不同的饱和功率和饱和时间来创建不同汇率的独特信号演变。将获取的信号与预定义的字典进行匹配以确定交换率。在CEST指纹识别的框架中还讨论了磁化转移效应：模拟字典可以预测没有磁化转移效应的信号曲线，并且将字典与所获取的信号进行比较可以校正磁化转移效应。在肌酸体模研究中，使用omega图将CEST指纹法与传统脉冲定量CEST法进行了比较。CEST指纹法具有显著减少的扫描时间（10分钟对50分钟），同时使用文献值作为参考提供更准确的汇率量化。在这项研究中，我们证明了CEST指纹是更有效的（5倍快）相比，脉冲定量CEST。实验结果表明，与脉冲定量CEST相比，3T下的CEST指纹技术的结果更接近文献值。
There is an increased interest to determine the exchange rate using CEST to provide pH information. However, current CEST quantification methods require lengthy scan times and do not address magnetization transfer effects. The purpose of this work was to apply the magnetic resonance fingerprinting (MRF) concept to CEST to achieve more efficient and accurate exchange rate quantification. The proposed CEST fingerprinting method used varying saturation powers and saturation times to create unique signal evolutions for different exchange rates. The acquired signal was matched to a predefined dictionary to determine the exchange rate. The magnetization transfer effects were also addressed in the framework of CEST fingerprinting: The simulated dictionary could predict the signal curves without magnetization transfer effects, and comparing the dictionary to the acquired signals allowed the correction of the magnetization transfer effects. The CEST fingerprinting method was compared with the conventional pulsed quantitative CEST method using omega plots in the creatine phantom study. The CEST fingerprinting method has a significantly reduced scan time (10 minutes versus 50 minutes) while providing more accurate exchange rate quantification using literature values as the reference. In this study, we demonstrate that CEST fingerprinting is more efficient (5 times faster) compared with pulsed quantitative CEST. It is also shown that the results of the proposed CEST fingerprinting technique are much closer to the literature values than pulsed quantitative CEST at 3 T.
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影响因子：
16.6
作者：
Cloos MA;Knoll F;Zhao T;Block KT;Bruno M;Wiggins GC;Sodickson DK
通讯作者：
Sodickson DK
影响因子：
3.3
作者：
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3.3
作者：
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通讯作者：
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影响因子：
3.3
作者：
Sheth, Vipul R.;Li, Yuguo;Chen, Liu Qi;Howison, Christine M.;Flask, Chris A.;Pagel, Mark D.
通讯作者：
Pagel, Mark D.
影响因子：
3.5
作者：
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通讯作者：
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