Basolateral Amygdala to Nucleus Accumbens Communication Differentially Mediates Devaluation Sensitivity of Sign- and Goal-Tracking Rats.
Basolateral Amygdala to Nucleus Accumbens Communication Differentially Mediates Devaluation Sensitivity of Sign- and Goal-Tracking Rats.
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DOI：
10.3389/fnbeh.2020.593645
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发表时间：
2020
影响因子：
3
通讯作者：
Calu DJ
中科院分区：
文献类型：
--
作者：
Kochli DE;Keefer SE;Gyawali U;Calu DJ
大鼠依靠杏仁基底外侧核(BLA)和伏隔核(NAC)之间的通讯，在巴甫洛夫杠杆自动成形(PLA)任务中表达杠杆定向方法，以区分手势跟踪和目标跟踪大鼠。在解放军期间，手势跟踪的大鼠优先接近可插入的杠杆线索，而目标跟踪的大鼠则接近提供奖励的食物杯。即使在相关的奖赏贬值后，手势跟踪大鼠对暗示的反应也是不灵活的，而目标跟踪大鼠在结果贬值期间灵活地减少了对暗示的反应。在这里，我们试图确定BLA-NAC交流是手势所必需的，但不是目标跟踪所必需的，是否驱动了对结果值操纵不敏感的手势跟踪大鼠的僵化食欲方法。使用对侧化学发生失活设计，我们向对侧BLA和NAC核心注入抑制性DREADD(hm4Di-mCherry)或对照(MCherry)结构。为了确定手势跟踪组和目标跟踪组，我们在五次解放军会议上训练了大鼠，在这些会议中，短暂的杠杆插入预测了食物颗粒的输送。在两种结果贬值探测试验中，我们先用训练丸(减值状态)或食物(高值状态)喂养大鼠，然后全身注射氯氮平(0.1 mg/kg)以灭活血乳酸和对侧NAC，其中我们测量杠杆和食品杯方法。对侧BLA-NAC化学生成失活促进了手势跟踪大鼠的灵活杠杆方法，但扰乱了目标跟踪大鼠的灵活食物杯方法。与先前的BLA-NAC断连损伤研究一致，我们发现对侧BLA和NAC核心的化学发生失活降低了水平，但不是在解放军中的食物杯方法。综上所述，这些发现表明，当结果值改变时，手势跟踪大鼠BLA-NAC中僵硬的食欲联想编码阻碍了灵活行为的表达。
Rats rely on communication between the basolateral amygdala (BLA) and nucleus accumbens (NAc) to express lever directed approach in a Pavlovian lever autoshaping (PLA) task that distinguishes sign- and goal-tracking rats. During PLA, sign-tracking rats preferentially approach an insertable lever cue, while goal-tracking rats approach a foodcup where rewards are delivered. While sign-tracking rats inflexibly respond to cues even after the associated reward is devalued, goal-tracking rats flexibly reduce responding to cues during outcome devaluation. Here, we sought to determine whether BLA–NAc communication, which is necessary for sign, but not goal-tracking, drives a rigid appetitive approach of sign-tracking rats that are insensitive to manipulations of outcome value. Using a contralateral chemogenetic inactivation design, we injected contralateral BLA and NAc core with inhibitory DREADD (hm4Di-mCherry) or control (mCherry) constructs. To determine sign- and goal-tracking groups, we trained rats in five PLA sessions in which brief lever insertion predicts food pellet delivery. We sated rats on training pellets (devalued condition) or chow (valued condition) before systemic clozapine injections (0.1 mg/kg) to inactivate BLA and contralateral NAc during two outcome devaluation probe tests, in which we measured lever and foodcup approach. Contralateral BLA–NAc chemogenetic inactivation promoted a flexible lever approach in sign-tracking rats but disrupted the flexible foodcup approach in goal-tracking rats. Consistent with a prior BLA–NAc disconnection lesion study, we find contralateral chemogenetic inactivation of BLA and NAc core reduces lever, but not the foodcup approach in PLA. Together these findings suggest rigid appetitive associative encoding in BLA–NAc of sign-tracking rats hinders the expression of flexible behavior when outcome value changes.
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影响因子：
3.3
作者：
Jones, J. L.;Day, J. J.;Wheeler, R. A.;Carelli, R. M.
通讯作者：
Carelli, R. M.
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
DOI：
10.1523/jneurosci.5119-12.2013
发表时间：
2013-02-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clark JJ;Collins AL;Sanford CA;Phillips PE
通讯作者：
Phillips PE
DOI：
10.1523/jneurosci.3758-08.2009
发表时间：
2009-01-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Johnson AW;Gallagher M;Holland PC
通讯作者：
Holland PC
DOI：
10.1101/lm.047365.118
发表时间：
2018-10
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Derman RC;Schneider K;Juarez S;Delamater AR
通讯作者：
Delamater AR