Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior.
Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior.
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DOI：
10.3389/fnbeh.2011.00050
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发表时间：
2011
影响因子：
3
通讯作者：
Tanaka M
中科院分区：
文献类型：
--
作者：
Watanabe Y;Tsujimura A;Takao K;Nishi K;Ito Y;Yasuhara Y;Nakatomi Y;Yokoyama C;Fukui K;Miyakawa T;Tanaka M
Relaxin-3 是属于松弛素/胰岛素超家族的神经肽。使用啮齿动物的研究表明，relaxin-3 主要在脑桥未定核 (NI) 的神经元中表达，该核的轴突投射到包括下丘脑在内的前脑区域。有证据表明relaxin-3 参与多种功能，包括食物摄入和应激反应。在本研究中，我们培育了松弛素 3 基因敲除 (KO) 小鼠，并使用一系列感觉/运动功能和情绪相关行为的行为测试对它们进行了检查。结果显示，relaxin-3 KO 小鼠表现出正常的生长和外观，通常与野生基因型同窝小鼠没有区别。至少在出生后 28 周之前，基因型之间的体重没有差异。此外，野生型和KO小鼠在运动活动、社交互动、热板测试表现、恐惧调节、抑郁样行为和Y迷宫测试表现方面没有显着差异。然而，在高架十字迷宫测试中，KO小鼠在进入开放臂的倾向方面表现出强劲的增加，尽管它们在光/暗转换测试中表现出正常的表现，并且在旷场测试中在中心区域花费的时间与野生型小鼠没有差异。另一方面，在 KO 小鼠中观察到声音惊吓反应显着增加。这些结果表明relaxin-3 轻微参与焦虑相关行为。
Relaxin-3 is a neuropeptide belonging to the relaxin/insulin superfamily. Studies using rodents have revealed that relaxin-3 is predominantly expressed in neurons in the nucleus incertus (NI) of the pons, the axons of which project to forebrain regions including the hypothalamus. There is evidence that relaxin-3 is involved in several functions, including food intake and stress responses. In the present study, we generated relaxin-3 gene knockout (KO) mice and examined them using a range of behavioral tests of sensory/motor functions and emotion-related behaviors. The results revealed that relaxin-3 KO mice exhibited normal growth and appearance, and were generally indistinguishable from wild genotype littermates. There was no difference in bodyweight among genotypes until at least 28 weeks after birth. In addition, there were no significant differences between wild-type and KO mice in locomotor activity, social interaction, hot plate test performance, fear conditioning, depression-like behavior, and Y-maze test performance. However, in the elevated plus maze test, KO mice exhibited a robust increase in the tendency to enter open arms, although they exhibited normal performance in a light/dark transition test and showed no difference from wild-type mice in the time spent in central area in the open field test. On the other hand, a significant increase in the acoustic startle response was observed in KO mice. These results indicate that relaxin-3 is slightly involved in the anxiety-related behavior.
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影响因子：
64.8
作者：
JAMES, R;NIALL, H;BRYANTGREENWOOD, G
通讯作者：
BRYANTGREENWOOD, G
影响因子：
--
作者：
McGowan, B. M.;Stanley, S. A.;Bloom, S. R.
通讯作者：
Bloom, S. R.
影响因子：
4
作者：
Reul, JMHM;Holsboer, F
通讯作者：
Holsboer, F
影响因子：
5.3
作者：
Risbrough, VB;Hauger, RL;Geyer, MA
通讯作者：
Geyer, MA
影响因子：
1.6
作者：
Anseloni, VZ;Brandao, ML
通讯作者：
Brandao, ML