Posterior Cingulate Cortex Network Predicts Alzheimer's Disease Progression.
Posterior Cingulate Cortex Network Predicts Alzheimer's Disease Progression.
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DOI：
10.3389/fnagi.2020.608667
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发表时间：
2020
影响因子：
4.8
通讯作者：
Lin CP
中科院分区：
文献类型：
--
作者：
Lee PL;Chou KH;Chung CP;Lai TH;Zhou JH;Wang PN;Lin CP
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是毒性错误折叠蛋白的积累，这些蛋白被认为是从疾病特异性中心通过大脑中相应的大规模结构网络传播的。尽管之前的横断面研究已经确定了潜在的ad相关中心和相应的大脑网络，但尚不清楚这些网络是否与疾病进展相关。因此，本研究旨在确定阿尔茨海默病早期最脆弱的震中和相应的大规模结构网络，并利用纵向研究设计评估其与多个认知领域的关联。对23名AD患者、37名遗忘性轻度认知障碍（MCI）患者和33名健康对照（HC）患者进行为期3年的年度神经心理学和MRI评估。候选中心被确定为进展为AD的MCI患者的灰质体积（GMV）下降速度比未进展的患者快的区域。然后将这些中心进一步用作预定义的感兴趣区域，以绘制hc中的同步退化网络（SDN）。利用空间相似性、网络偏好和临床关联分析来评估所识别的sdn的具体作用。我们的研究结果表明，海马和后扣带皮层（PCC）是ad相关的最脆弱的震中。各患者组相应的PCC-SDN与GMV萎缩率模式存在显著的空间相关性，且在疾病晚期这些模式的重叠更为明显。此外，PCC-SDN GMV萎缩率较高的个体在多个认知领域也表现出更快的衰退。总之，我们的研究结果表明，PCC和海马是阿尔茨海默病病理生理早期参与的两个易感区域。然而，PCC-SDN，而不是海马- sdn，与AD的进展更密切相关。这些结果可能从大尺度网络的角度深入了解AD的病理生理。
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of toxic misfolded proteins, which are believed to have propagated from disease-specific epicenters through their corresponding large-scale structural networks in the brain. Although previous cross-sectional studies have identified potential AD-associated epicenters and corresponding brain networks, it is unclear whether these networks are associated with disease progression. Hence, this study aims to identify the most vulnerable epicenters and corresponding large-scale structural networks involved in the early stages of AD and to evaluate its associations with multiple cognitive domains using longitudinal study design. Annual neuropsychological and MRI assessments were obtained from 23 patients with AD, 37 patients with amnestic mild cognitive impairment (MCI), and 33 healthy controls (HC) for 3 years. Candidate epicenters were identified as regions with faster decline rate in the gray matter volume (GMV) in patients with MCI who progressed to AD as compared to those regions in patients without progression. These epicenters were then further used as pre-defined regions of interest to map the synchronized degeneration network (SDN) in HCs. Spatial similarity, network preference and clinical association analyses were used to evaluate the specific roles of the identified SDNs. Our results demonstrated that the hippocampus and posterior cingulate cortex (PCC) were the most vulnerable AD-associated epicenters. The corresponding PCC-SDN showed significant spatial association with the patterns of GMV atrophy rate in each patient group and the overlap of these patterns was more evident in the advanced stages of the disease. Furthermore, individuals with a higher GMV atrophy rate of the PCC-SDN also showed faster decline in multiple cognitive domains. In conclusion, our findings suggest the PCC and hippocampus are two vulnerable regions involved early in AD pathophysiology. However, the PCC-SDN, but not hippocampus-SDN, was more closely associated with AD progression. These results may provide insight into the pathophysiology of AD from large-scale network perspective.
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影响因子：
25
作者：
King M;Hernandez-Castillo CR;Poldrack RA;Ivry RB;Diedrichsen J
通讯作者：
Diedrichsen J
DOI：
10.1017/s1355617709991184
发表时间：
2010-03
影响因子：
2.6
作者：
Chang, Chiung Chih;Kramer, Joel H.;Lin, Ker Neng;Chang, Wen Neng;Wang, Ya-Ling;Huang, Chi-Wei;Lin, Yu Ting;Chen, Ching;Wang, Pei Ning
通讯作者：
Wang, Pei Ning
DOI：
10.1523/jneurosci.3554-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Alexander-Bloch A;Raznahan A;Bullmore E;Giedd J
通讯作者：
Giedd J
影响因子：
16.2
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Sepulcre, Jorge;Poulin, Renee;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.