The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.
The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.
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HBA1C在低密度脂蛋白胆固醇水平升高与糖尿病周围神经病在2型糖尿病患者中的介导作用。
DOI：
10.1186/s12944-023-01865-5
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发表时间：
2023-07-13
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
低密度脂蛋白胆固醇（LDL - C）水平升高已被确定为患者发生糖尿病周围神经病变（DPN）的潜在危险因素之一。本研究旨在阐明2型糖尿病（T2DM）患者中LDL - C、高血糖与DPN之间的联系。
在此，共招募了120名T2DM患者。这些T2DM志愿者根据是否存在周围神经病变被分为两组。此外，还对他们的基线特征进行了比较。分析了LDL - C和糖化血红蛋白（HbA1c）水平与DPN之间的关联，特别是与特定神经传导速度的关系。为确定影响DPN的因素，进行了回归分析。此外，采用中介效应分析，以HbA1c作为中介变量，评估LDL - C对特定神经传导速度的间接、直接和总效应。
与55名无DPN的患者相比，65名DPN患者的LDL - C和HbA1c水平升高。研究发现，LDL - C和HbA1c均与糖尿病患者尺神经（或腓总神经）运动纤维传导速度降低有关。HbA1c是T2DM患者发生DPN的已知危险因素之一。进一步的中介效应分析显示，在T2DM患者中，LDL - C对尺神经（或腓总神经）运动纤维传导速度的影响完全由HbA1c介导。
研究发现，T2DM患者中LDL - C水平升高对尺神经（或腓总神经）运动纤维传导速度的影响完全是由HbA1c水平升高所介导的。
在线版本包含补充材料，网址为10.1186/s12944 - 023 - 01865 - 5 。
Increased levels of low-density lipoprotein cholesterol (LDL-C) have been identified as one potential risk factor for diabetic peripheral neuropathy (DPN) in patients. The current study seeks to clarify the link between LDL-C, hyperglycemia, and DPN in patients with type 2 diabetes mellitus (T2DM). Here, a total of 120 T2DM individuals were recruited. These volunteers with T2DM were divided into 2 groups, based on the presence or absence of peripheral neuropathy. Additionally, their baseline characteristics were compared. Association among LDL-C and glycosylated hemoglobin (HbA1c) levels and DPN, particularly with respect to specific nerve conduction velocity were analyzed. To identify factors influencing DPN, regression was performed. Furthermore, mediation analysis was employed to evaluate the indirect, direct and total effects of LDL-C on specific nerve conduction velocity, with HbA1c serving as a mediator. Compared to 55 patients without DPN, 65 patients with DPN demonstrated elevated levels of LDL-C and HbA1c. Both LDL-C and HbA1c have been found to be associated with reduced the motor fiber conduction velocities of Ulnar (or the Common peroneal) nerve in diabetic patients. HbA1c is one of the known risk factors for DPN in individuals with T2DM. Further mediation analysis revealed that the effect of LDL-C on the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities are fully mediated by HbA1c in patients with T2DM. The impact of elevated LDL-C levels upon the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities in patients with T2DM was found to be entirely mediated by increased HbA1c levels. The online version contains supplementary material available at 10.1186/s12944-023-01865-5.
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影响因子：
3.7
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