A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women.
A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women.
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DOI：
10.3390/nu13030760
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发表时间：
2021-02-26
期刊：
影响因子：
5.9
通讯作者：
Stanhope KL
中科院分区：
文献类型：
--
作者：
Price CA;Medici V;Nunez MV;Lee V;Sigala DM;Benyam Y;Keim NL;Mason AE;Chen SY;Parenti M;Slupsky C;Epel ES;Havel PJ;Stanhope KL
过量饮用含糖饮料会增加与心脏代谢疾病相关的风险因素，部分原因是肝脏果糖超负荷。然而，目前尚不清楚含有果糖作为天然糖的饮料是否会产生与含有添加糖的饮料相同的代谢失调。我们比较了饮用天然甜味橙子汁（OJ）或蔗糖甜味饮料（sucrose-SB）两周对心脏代谢疾病危险因素的影响。健康、超重的女性（n = 20）被分配每天食用3份100%橙子汁或蔗糖SB。我们在基线和2周饮食干预后的30小时住院访视期间进行了16小时连续采血和3小时口服葡萄糖耐量试验。与食用OJ的受试者相比，食用蔗糖SB的受试者的尿酸曲线下面积（AUC）增加。与蔗糖SB不同，OJ没有显着增加空腹或餐后脂蛋白。两种饮料的摄入均导致Matsuda胰岛素敏感性指数降低（OJ：−0.40 ± 0.18，组内p = 0.04;蔗糖-SB：−1.0 ± 0.38，组内p = 0.006;组间p = 0.53）。这项初步研究的结果表明，与蔗糖-SB相比，在当前膳食指南的糖摄入量以上的水平上食用OJ不会增加血浆尿酸浓度，但似乎会导致胰岛素敏感性的可比降低。
Overconsumption of sugar-sweetened beverages increases risk factors associated with cardiometabolic disease, in part due to hepatic fructose overload. However, it is not clear whether consumption of beverages containing fructose as naturally occurring sugar produces equivalent metabolic dysregulation as beverages containing added sugars. We compared the effects of consuming naturally-sweetened orange juice (OJ) or sucrose-sweetened beverages (sucrose-SB) for two weeks on risk factors for cardiometabolic disease. Healthy, overweight women (n = 20) were assigned to consume either 3 servings of 100% orange juice or sucrose-SB/day. We conducted 16-hour serial blood collections and 3-h oral glucose tolerance tests during a 30-h inpatient visit at baseline and after the 2-week diet intervention. The 16-h area under the curve (AUC) for uric acid increased in subjects consuming sucrose-SB compared with subjects consuming OJ. Unlike sucrose-SB, OJ did not significantly increase fasting or postprandial lipoproteins. Consumption of both beverages resulted in reductions in the Matsuda insulin sensitivity index (OJ: −0.40 ± 0.18, p = 0.04 within group; sucrose-SB: −1.0 ± 0.38, p = 0.006 within group; p = 0.53 between groups). Findings from this pilot study suggest that consumption of OJ at levels above the current dietary guidelines for sugar intake does not increase plasma uric acid concentrations compared with sucrose-SB, but appears to lead to comparable decreases of insulin sensitivity.
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影响因子：
--
作者：
Azzini E;Venneria E;Ciarapica D;Foddai MS;Intorre F;Zaccaria M;Maiani F;Palomba L;Barnaba L;Tubili C;Maiani G;Polito A
通讯作者：
Polito A
影响因子：
6.1
作者：
Fidelix, Melaine;Milenkovic, Dragan;Cesar, Thais
通讯作者：
Cesar, Thais
影响因子：
4.7
作者：
Juraschek, Stephen P.;Miller, Edgar R., III;Gelber, Allan C.
通讯作者：
Gelber, Allan C.
影响因子：
2.5
作者：
Gorgus, Eva;Hittinger, Maike;Schrenk, Dieter
通讯作者：
Schrenk, Dieter
DOI：
10.1016/j.biocel.2005.10.002
发表时间：
2006-01-01
影响因子：
4
作者：
Li, JM;Che, CT;Cheng, CHK
通讯作者：
Cheng, CHK