Differences in learning and memory between middle-aged female and male rats.
Differences in learning and memory between middle-aged female and male rats.
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DOI：
10.1101/lm.053578.122
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发表时间：
2022-05
影响因子：
2
通讯作者：
Jerusalinsky, Diana Alicia
中科院分区：
文献类型：
--
作者：
Colettis, Natalia Claudia;Habif, Martin;Oberholzer, Maria Victoria;Filippin, Federico;Jerusalinsky, Diana Alicia
我们观察了中年雌性和雄性Wistar大鼠认知功能的差异。两人（像年轻人一样）都能区分新物体和熟悉物体，表现出相似的短期和长期记忆（分别为STM和LTM）。只有女性表现出强大的LTM的对象的新位置。两者都成功地形成了抑制性回避的LTM，尽管男性似乎对记忆持续性有遗忘症。习惯，运动，水平探索，“刻板印象”，恐惧和焦虑样行为都是相似的，而垂直探索显着较高的中年和年轻女性。因此，在设计和解释学习和记忆研究时，必须考虑某些认知功能和行为的性别差异。
We observed differences in cognitive functions between middle-aged female and male Wistar rats. Both (like youngsters) discriminated new versus familiar objects, showing similar short- and long-term memory (STM and LTM, respectively). Only females show robust LTM for new location of an object. Both successfully form LTM of inhibitory avoidance, though males appeared to be amnesic for memory persistence. Habituation, locomotion, horizontal exploration, “stereotypies,” fear, and anxiety-like behavior were similar for both, while vertical exploration was significantly higher in middle-aged and younger females. Therefore, sex-dependent differences in some cognitive functions and behaviors must be considered when designing and interpreting learning and memory studies.
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影响因子：
3.3
作者：
Loi, M.;Mossink, J. C. L.;Joels, M.
通讯作者：
Joels, M.
影响因子：
2.9
作者：
JOHNSTON, AL;FILE, SE
通讯作者：
FILE, SE
影响因子：
3.3
作者：
Belviranli, M.;Atalik, K. E. N.;Gokbel, H.
通讯作者：
Gokbel, H.
影响因子：
4.1
作者：
Mateos, B.;Borcel, E.;Viveros, M-P
通讯作者：
Viveros, M-P
DOI：
10.1016/0163-1047(92)90387-j
发表时间：
1992-09-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
MEANS, LW;ALEXANDER, SR;ONEAL, MF
通讯作者：
ONEAL, MF