Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI.
Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI.
复制标题
静息态功能 MRI 揭示特发性震颤患者异常区域均匀性
DOI：
10.1371/journal.pone.0069199
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Fang W;Lv F;Luo T;Cheng O;Liao W;Sheng K;Wang X;Wu F;Hu Y;Luo J;Yang QX;Zhang H
原发性震颤(ET)是成人最常见的运动障碍之一。它可以被描述为一种进行性神经障碍，其最明显的特征是手臂或手的震颤，在进食和写作等自愿运动中表现得很明显。ET的病理机制尚不清楚。静息状态功能磁共振成像(RS-fMRI)作为一种非侵入性成像技术，用于研究脑内ET的功能连接异常。用区域同质性(ReHo)作为RS-fMRI的指标，评价20例ET患者和20例年龄、性别匹配的健康对照(HC)的局部功能连接异常。ET组双侧小脑前叶、后叶、双侧丘脑和岛叶的ReHO降低，双侧额叶、顶叶、左侧初级运动皮质和左侧辅助运动区的ReHO升高。ET患者双侧小脑前叶和右侧小脑后叶的REHO值异常与震颤严重程度评分呈负相关，与左侧初级运动皮质的REHO值呈正相关。提示小脑-丘脑-皮质运动通路异常参与了震颤的发生和传播，可能与ET患者的运动相关症状有关。同时，额前区和顶区的异常可能与ET的非运动症状有关。这些结果提示，ReHO可用于研究ET的功能病理机制。
Essential tremor (ET) is one of the most common movement disorders in human adults. It can be characterized as a progressive neurological disorder of which the most recognizable feature is a tremor of the arms or hands that is apparent during voluntary movements such as eating and writing. The pathology of ET remains unclear. Resting-state fMRI (RS-fMRI), as a non-invasive imaging technique, was employed to investigate abnormalities of functional connectivity in ET in the brain. Regional homogeneity (ReHo) was used as a metric of RS-fMRI to assess the local functional connectivity abnormality in ET with 20 ET patients and 20 age- and gender-matched healthy controls (HC). The ET group showed decreased ReHo in the anterior and posterior bilateral cerebellar lobes, the bilateral thalamus and the insular lobe, and increased ReHo in the bilateral prefrontal and parietal cortices, the left primary motor cortex and left supplementary motor area. The abnormal ReHo value of ET patients in the bilateral anterior cerebellar lobes and the right posterior cerebellar lobe were negatively correlated with the tremor severity score, while positively correlated with that in the left primary motor cortex. These findings suggest that the abnormality in cerebello-thalamo-cortical motor pathway is involved in tremor generation and propagation, which may be related to motor-related symptoms in ET patients. Meanwhile, the abnormality in the prefrontal and parietal regions may be associated with non-motor symptoms in ET. These findings suggest that the ReHo could be utilized for investigations of functional-pathological mechanism of ET.
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14.5
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