Genomic characterization of Campylobacter jejuni strain M1.
Genomic characterization of Campylobacter jejuni strain M1.
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DOI：
10.1371/journal.pone.0012253
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发表时间：
2010-08-26
期刊：
影响因子：
3.7
通讯作者：
Ussery DW
中科院分区：
文献类型：
--
作者：
Friis C;Wassenaar TM;Javed MA;Snipen L;Lagesen K;Hallin PF;Newell DG;Toszeghy M;Ridley A;Manning G;Ussery DW
空肠弯曲杆菌菌株M1（实验室编号99/308）是一种罕见的直接传播C。空肠从鸡到人，造成肠炎。我们对C. jejuni菌株M1，并与其它12株C.空肠测序基因组目前公开。M1与81116菌株的亲缘关系最近。根据这13个基因组序列，我们鉴定了C.空肠全基因组，以及核心基因组，辅助基因，和菌株M1和81116之间的独特基因。泛基因组包含2，427个基因家族，而核心基因组包含1，295个基因家族，约为测序的C.空肠基因组。各种比较和可视化工具应用于13 C。jejuni基因组序列，包括物种泛基因组图和核心基因组图、BLAST矩阵和BLAST图谱。基于16 S rRNA序列和每个基因组中的总基因家族的树。研究结果进行了讨论的背景下证明的毒力潜力的M1。
Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C. jejuni strain M1, and compared this to 12 other C. jejuni sequenced genomes currently publicly available. Compared to these, M1 is closest to strain 81116. Based on the 13 genome sequences, we have identified the C. jejuni pan-genome, as well as the core genome, the auxiliary genes, and genes unique between strains M1 and 81116. The pan-genome contains 2,427 gene families, whilst the core genome comprised 1,295 gene families, or about two-thirds of the gene content of the average of the sequenced C. jejuni genomes. Various comparison and visualization tools were applied to the 13 C. jejuni genome sequences, including a species pan- and core genome plot, a BLAST Matrix and a BLAST Atlas. Trees based on 16S rRNA sequences and on the total gene families in each genome are presented. The findings are discussed in the background of the proven virulence potential of M1.
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影响因子：
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Gibson, J;Lorenz, E;Owen, RJ
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通讯作者：
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