Impaired integrity of commissural and association fibers in essential tremor patients: Evidence from a diffusion tensor imaging study.
Impaired integrity of commissural and association fibers in essential tremor patients: Evidence from a diffusion tensor imaging study.
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DOI：
10.3906/sag-2004-305
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发表时间：
2021-02-26
影响因子：
2.3
通讯作者：
Alkan A
中科院分区：
文献类型：
--
作者：
Tantik Pak A;Şengül Y;Otcu Temur H;Alkan A
对特发性震颤（ET）的不断发展的理解导致了神经退行性疾病的新定义，指出弥漫性脑网络参与广泛的相关运动和非运动症状。考虑到白色物质也会受到疾病性质的影响，我们的研究旨在评估ET患者白色物质的完整性及其临床相关性。 大约40名被诊断患有ET的患者和40名年龄和性别匹配的对照受试者（范围在18-80岁之间）被纳入研究。记录患者的社会人口学特征和临床特征。使用Fahn-Tolosa-Marin震颤评定量表（FTM-TRS）评估震颤。采用弥散张量成像（DTI）评价白色物质的完整性。用于DTI评估的所选白色物质区域是胼胝体（CC）（即，人脑中最大的连合束）、上级纵束（SLF）和下级纵束（ILF）（即，最大的联合纤维束）。 ET组和对照组的平均年龄分别为44.23 ± 18.91岁和37.45 ± 10.95岁（P = 0.542）。CC体的各向异性分数（FA）值（P = 0.003）、ILF（p = 0.016）、CC体的平均扩散系数（ADC）值（p = 0.001）、ADC值（P = 0.049）、SLF（V < 0.001）和ILF（P < 0.001）在组间存在差异。在控制了年龄和性别后，震颤严重程度与DTI参数无相关性，但CC FA区（P = 0.035，r = 0.442）和CC ADC压区（P = 0.007，r = 0.543）的完整性受损与震颤持续时间较长有关。阳性家族史与CC FA和ADC压位（P = 0.008，r = 0.536; P = 0.027，r = 0.461）及ILF ADC压位（P = 0.011，r = -0.519）相关。 在我们的研究中，主要的白色物质结构的变化被发现在ET患者。结果表明，可能的神经变性也影响白色物质结构在ET患者和震颤的持续时间和家族史与受损的完整性白色物质。
The evolving understanding of essential tremors (ET) has led to a new definition of neurodegenerative disease, pointing to diffuse brain network involvement with a wide spectrum of associated motor and nonmotor symptoms. Considering the fact that white matter should also be affected by the nature of the disease, our study aimed to evaluate the integrity of white matter and its clinical correlations in ET patients. Approximately 40 patients diagnosed with ET and 40 age-and sex-matched control subjects (ranging between 18–80 years old) were included in the study. The sociodemographic characteristics and clinical features of the patients were recorded. Tremors were assessed using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). Diffusion Tensor Imaging (DTI) was performed to evaluate the integrity of white matter. The selected white matter regions used for DTI assessment were the corpus callosum (CC) (i.e., the largest commissural tract in the human brain), the superior longitudinal fasciculus (SLF), and the inferior longitudinal fasciculus (ILF) (i.e., the largest association fiber bundles). The mean age of the ET patients and control subjects was 44.23 ± 18.91 and 37.45 ± 10.95 years old (P = 0.542). The fractional anisotropy (FA) values of the CC body (P = 0.003), ILF (p = 0.016), average diffusion coefficient (ADC) values of the CC body (p = 0.001), genu (P = 0.049), SLF (V < 0.001), and ILF (P < 0.001) differed between groups. After controlling for age and sex, there was no correlation between tremor severity and DTI parameters, but impaired integrity in the genu of CC FA (P = 0.035, r = 0.442) and the splenium of CC ADC (P = 0.007, r = 0.543) were related with a longer duration of tremor. Finally, positive family history was correlated with the splenium of CC FA and ADC (P = 0.008, r = 0.536; P = 0.027, r = 0.461) and ILF ADC (P = 0.011, r = –0.519). In our study, major white matter structure changes were found in the ET patients. The results suggest that possible neurodegeneration also affects white matter structures in ET patients and that the duration of the tremor and family history are related with impaired integrity of white matter.
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DOI：
10.12659/msm.906437
发表时间：
2018-05-13
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Cao H;Wang R;Luo X;Li X;Hallett M;Thompson-Westra J;Yang J;Qu Q;Yang X
通讯作者：
Yang X
影响因子：
4.4
作者：
Benito-Leon, Julian;Alvarez-Linera, Juan;Louis, Elan D.
通讯作者：
Louis, Elan D.
影响因子：
9.9
作者：
Daniels, C.;Peller, M.;Deuschl, G.
通讯作者：
Deuschl, G.
影响因子：
9.9
作者：
Dogu, O;Sevim, S;Louis, ED
通讯作者：
Louis, ED
影响因子：
5.1
作者：
Louis, E. D.;Benito-Leon, J.;Bermejo-Pareja, F.
通讯作者：
Bermejo-Pareja, F.