Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study.
Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study.
复制标题
DOI：
10.1136/ard.2009.110114
复制
发表时间：
2010-05
影响因子：
27.4
通讯作者：
Felson D
中科院分区：
文献类型：
--
作者：
Neogi T;Nevitt M;Niu J;Sharma L;Roemer F;Guermazi A;Lewis CE;Torner J;Javaid K;Felson D
软骨下骨磨损 (SBA) 是骨关节炎的一个特征，可能是由于骨局部负荷过大和/或骨质量不足以承受关节负荷而引起的。本研究评估了排列不正（可能导致局灶性过度负荷）和全身骨密度对 SBA 存在和发生率的影响。多中心骨关节炎研究是一组患有膝骨关节炎或处于高风险膝骨关节炎的个体。评估基线对齐和骨矿物质密度（BMD）测量。使用全器官磁共振成像评分对基线和 30 个月膝关节磁共振图像进行 SBA 分级（0-3 级）。该研究使用逻辑回归并调整年龄、性别和体重指数，分别评估了内侧和外侧间室的排列以及全身 BMD 与 SBA 和事件 SBA 基线存在的关联。在 1253 名参与者中（平均年龄 62 岁，平均 BMI 30，61% 为女性），33% 患有基线 SBA，44% 患有膝骨关节炎。注意到 SBA 的存在和发生率与两个间室排列不正之间的关联（内侧间室内翻膝的比值比 (95% CI) 分别为 2.9（2.1 至 4.0）和 1.9（1.2 至 2.9）；外翻膝分别为 4.5（2.8 至 7.1）和 2.1（1.1 至 4.1）。侧室）。低 BMD 与 SBA 无关。 SBA 的存在和发生率与隔室特异性的排列不良相关，但与低 BMD 无关。 SBA 可能是上层软骨承受的负荷增加的标志，这可能导致由于软骨下骨的改变而导致传递到软骨的力增加。
Subchondral bone attrition (SBA), a feature of osteoarthritis, may be caused by excess focal load to bone, and/or inadequate bone quality to withstand loads through the joint. This study evaluated the effects of malalignment, which can cause focal excessive load, and systemic bone density on the presence and incidence of SBA. The Multicenter Osteoarthritis Study is a cohort of individuals who have or are at high risk of knee osteoarthritis. Baseline alignment and bone mineral density (BMD) measures were assessed. Baseline and 30-month knee magnetic resonance images were graded for SBA (grade 0–3) using the whole-organ magnetic resonance imaging score. The study evaluated the association of alignment in medial and lateral compartments, respectively, and systemic BMD with baseline presence of SBA and incident SBA using logistic regression and adjusting for age, sex and body mass index. Of 1253 participants (mean age 62 years, mean BMI 30, 61% women), 33% had baseline SBA and 44% had knee osteoarthritis. Associations between the presence and incidence of SBA with malalignment in both compartments were noted (odds ratios (95% CI) 2.9 (2.1 to 4.0) and 1.9 (1.2 to 2.9), respectively, for varus knees in the medial compartment; 4.5 (2.8 to 7.1) and 2.1 (1.1 to 4.1), respectively, for valgus knees in the lateral compartment). Low BMD was not associated with SBA. The presence and incidence of SBA are associated with malalignment in a compartment-specific manner, but not with low BMD. SBA may be a marker of increased load experienced by overlying cartilage, which may contribute to increased forces transmitted to the cartilage due to alteration in subchondral bone.
登录
查看更多内容
影响因子：
--
作者：
DEDRICK, DK;GOLDSTEIN, SA;ALBRECHT, M
通讯作者：
ALBRECHT, M
影响因子：
27.4
作者：
Hernandez-Molina, G.;Neogi, T.;Felson, D. T.
通讯作者：
Felson, D. T.
DOI：
10.1016/j.biocel.2004.06.016
发表时间：
2005-01-01
影响因子：
4
作者：
Anderson-MacKenzie, JM;Quasnichka, HL;Bailey, AJ
通讯作者：
Bailey, AJ
DOI：
10.1302/0301-620x.85b6.12595
发表时间：
2003-08-01
影响因子：
--
作者：
Ding, M;Odgaard, A;Hvid, I
通讯作者：
Hvid, I
影响因子：
--
作者：
Englund, Martin;Guermazi, Ali;Roemer, Frank W.;Aliabadi, Piran;Yang, Mei;Lewis, Cora E.;Torner, James;Nevitt, Michael C.;Sack, Burton;Felson, David T.
通讯作者：
Felson, David T.