Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers.
Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers.
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结直肠癌是美国 50 岁以下成年人癌症发病率和死亡率的主要原因：一项基于 SEER 的分析，与其他年轻发病的癌症进行比较。
DOI：
10.1136/jim-2016-000229
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Bhandari A;Woodhouse M;Gupta S
结直肠癌（CRC）的发病率和死亡率在年轻人中呈上升趋势。我们的目的是对比美国年轻人中结直肠癌与其他常见癌症的相对发病率和死亡率。我们使用监测、流行病学和最终结果登记数据来比较年龄小于50岁的成年人癌症特定部位和特定年龄的死亡率和发病率。我们总结了提取的数据，包括总体数据和按性别分层的数据。我们发现，在50岁以下的成年人中，结直肠癌是癌症死亡的第三大原因，仅次于乳腺癌和肺癌（每10万人中有1.67例）。在年轻女性中，结直肠癌是癌症死亡的第四大原因（每10万人中有1.51人）。在年轻男性中，结直肠癌是癌症死亡的第二大原因（每10万人中有1.82例）。结直肠癌是年轻男性和女性中发病率第二高的癌症。在男性中，结直肠癌是30岁以后发病率第二高的癌症，在30 - 34岁、35-39岁、40-44岁和45-49岁的人群中，每10万人中分别有4.9、9.0、16.4和30.8例。在女性中，30-34岁、35-39岁、40-44岁和45-49岁的CRC发病率相似，分别为4.2、7.6、15.3和25.9 / 10万。这些结果表明，相对于其他癌症，结直肠癌是美国年轻人癌症发病率和死亡率的主要原因。考虑到年轻人结直肠癌发病率上升的趋势，确定可能从早期筛查开始获益的年轻发病结直肠癌风险个体的策略值得研究。
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1.67 cases per 100,000). Among young women, CRC was the fourth leading cause of cancer death (1.51 per 100,000). Among young men, CRC was the second leading cause of cancer death (1.82 cases per 100,000). CRC was the second most incident cancer among young adults for men and women combined. Among men, CRC was the second most incident cancer after age 30, with 4.9, 9.0, 16.4, and 30.8 cases per 100,000 for ages 30–34, 35–39, 40–44, and 45–49 years, respectively. Among women, CRC incidence was similar with 4.2, 7.6, 15.3, and 25.9 cases per 100,000 for ages 30–34, 35–39, 40–44, and 45–49 years, respectively. These results show that CRC is a leading cause of cancer incidence and mortality among young adults in the USA, relative to other cancers. Given trends toward increasing rates of CRC among young adults, strategies for identifying individuals at risk for young-onset CRC who might benefit from early age of screening initiation merit investigation.
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254.7
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