Can the world's favorite fruit, tomato, provide an effective biosynthetic chassis for high-value metabolites?
Can the world's favorite fruit, tomato, provide an effective biosynthetic chassis for high-value metabolites?
复制标题
世界上最受欢迎的水果番茄能否为高价值代谢物提供有效的生物合成基础？
DOI：
10.1007/s00299-018-2283-8
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发表时间：
2018-10
影响因子：
6.2
通讯作者：
Martin C
中科院分区：
文献类型：
--
作者：
Li Y;Wang H;Zhang Y;Martin C
番茄具有相对短的生长周期（从种植起65-85天内即可采摘果实）和相对高的产量（地球仪番茄的平均产量为每株3-9 kg果实，最高可达每株40 kg果实）。番茄还产生大量重要的初级和次级代谢产物，这些代谢产物可以作为生产有价值的新化合物的中间体或底物。作为一种示范作物，番茄已经拥有广泛的生物技术应用工具和资源，可以增加促进健康的生物强化食品的营养，也可以作为高价值化合物的生产系统。这些优点使番茄成为生产重要代谢物的优良底盘。本文综述了番茄代谢工程的最新研究成果，并提出了番茄代谢工程的新目标。我们提供了一个计划，如何建立番茄作为底盘的工业规模生产的高价值的代谢产物。
Tomato has a relatively short growth cycle (fruit ready to pick within 65–85 days from planting) and a relatively high yield (the average for globe tomatoes is 3–9 kg fruit per plant rising to as much as 40 kg fruit per plant). Tomatoes also produce large amounts of important primary and secondary metabolites which can serve as intermediates or substrates for producing valuable new compounds. As a model crop, tomato already has a broad range of tools and resources available for biotechnological applications, either increased nutrients for health-promoting biofortified foods or as a production system for high-value compounds. These advantages make tomato an excellent chassis for the production of important metabolites. We summarize recent achievements in metabolic engineering of tomato and suggest new candidate metabolites which could be targets for metabolic engineering. We offer a scheme for how to establish tomato as a chassis for industrial-scale production of high-value metabolites.
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影响因子：
6.5
作者：
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通讯作者：
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