Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield.
Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield.
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DOI：
10.1016/j.biopsych.2010.04.035
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发表时间：
2010-09-01
影响因子：
10.6
通讯作者：
Schuff, Norbert
中科院分区：
文献类型：
--
作者：
Neylan, Thomas C.;Mueller, Susanne G.;Wang, Zhen;Metzler, Thomas J.;Lenoci, Maryann;Truran, Diana;Marmar, Charles R.;Weiner, Michael W.;Schuff, Norbert
关键词：
在动物实验中，长时间的睡眠中断与齿状回神经发生减少有关。我们的目的是确定创伤后应激障碍样本和对照组的失眠严重程度是否与CA3/齿状海马亚区体积减少有关。采用4台特斯拉MRI对17例（41±12岁）PTSD阳性退伍军人和19例同龄PTSD阴性退伍军人的海马亚区体积进行了测量。主观睡眠质量通过失眠严重指数（ISI）和匹兹堡睡眠质量指数（PSQI）来衡量。ISI得分越高，失眠越严重，CA3/齿状子区体积越小（r=−）。48, p < 0.01)。在首先控制年龄和PTSD症状后，将ISI评分作为CA3/齿状体积的预测因子加入到层次线性回归模型中，增量方差增加了13% （t= - 2.47, p= 0.02）。研究结果首次表明，人类失眠的严重程度与CA3/齿状子区体积损失有关。这与动物研究一致，表明慢性睡眠中断与这些结构中的神经发生和树突分支减少有关。
Prolonged disruption of sleep in animal studies is associated with decreased neurogenesis in the dentate gyrus. Our objective was to determine if insomnia severity in a sample of PTSD and controls was associated with decreased volume in the CA3/dentate hippocampal subfield. Volumes of hippocampal subfields in seventeen veteran males positive for PTSD (41 ±12 years) and nineteen age-matched male veterans negative for PTSD were measured using 4 Tesla MRI. Subjective sleep quality was measured by the Insomnia Severity Index (ISI) and the Pittsburgh Sleep Quality Index (PSQI). Higher scores on the ISI, indicating worse insomnia, were associated with smaller volumes of the CA3/dentate subfields (r= −.48, p < 0.01) in the combined sample. Adding the ISI score as a predictor for CA3/dentate volume to a hierarchical linear regression model after first controlling for age and PTSD symptoms accounted for a 13 % increase in incremental variance (t= −2.47, p= 0.02). The findings indicate for the first time in humans that insomnia severity is associated with volume loss of the CA3/dentate subfields. This is consistent with animal studies showing that chronic sleep disruption is associated with decreased neurogenesis and dendritic branching in these structures.
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影响因子：
2.3
作者：
Schuff, Norbert;Neylan, Thomas C.;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
成人大脑中的新神经元：睡眠的作用和睡眠损失的后果。
影响因子：
10.5
作者：
Meerlo, Peter;Mistiberger, Ralph E.;Jacobs, Barry L.;Heller, H. Craig;McGinty, Dennis
通讯作者：
McGinty, Dennis
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
5.7
作者：
Mueller, S. G.;Schuff, N.;Weiner, M. W.
通讯作者：
Weiner, M. W.
影响因子：
3.3
作者：
Guzman-Marin, R.;Bashir, T.;McGinty, D.
通讯作者：
McGinty, D.