PUMA - pooled uranium miners analysis: cohort profile.
PUMA - pooled uranium miners analysis: cohort profile.
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DOI：
10.1136/oemed-2019-105981
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发表时间：
2020-03
影响因子：
4.9
通讯作者：
Laurier D
中科院分区：
文献类型：
--
作者：
Rage E;Richardson DB;Demers PA;Do M;Fenske N;Kreuzer M;Samet J;Wiggins C;Schubauer-Berigan MK;Kelly-Reif K;Tomasek L;Zablotska LB;Laurier D
对地下矿工的流行病学研究提供了明确的证据，表明接触氡衰变产物会导致肺癌。此外，这些研究还为估计与氡相关的过量肺癌风险提供了量化基础。然而，暴露在当代职业和环境环境中通常遇到的低水平氡衰变产物对肺癌和其他疾病风险的影响以及对这些联系的修饰物的影响仍然存在问题。这些问题对于估计与住宅和职业氡暴露有关的风险至关重要。联合铀矿者分析研究是迄今为止对铀矿者进行的最大规模的研究，涵盖了124,507名矿工，451万人年的风险，以及54,462人的死亡，包括7,825人死于肺癌。可获得的数据包括个人对氡衰变产品暴露的年度估计、每个工人的人口统计和就业历史信息，以及关于生命状况、死亡日期和死因的信息。有些人，但不是所有人，也有关于吸烟、外部伽马辐射暴露和非放射性职业暴露的个人信息。总而言之，PUMA提供了机会来评估新的研究问题，并进行分析以评估与铀开采有关的潜在健康风险，这些风险具有比任何单一队列所能实现的更大的统计能力。
Epidemiological studies of underground miners have provided clear evidence that exposure to radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. The Pooled Uranium Miner Analysis (PUMA) study represents the largest study of uranium miners conducted to-date, encompassing 124,507 miners, 4.51 million person-years at risk, and 54,462 deaths, including 7,825 deaths due to lung cancer. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker, and information on vital status, date of death, and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure, and non-radiological occupational exposures. In summary, PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.
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影响因子：
8.8
作者：
Kreuzer, M.;Walsh, L.;Schnelzer, M.;Tschense, A.;Grosche, B.
通讯作者：
Grosche, B.
影响因子：
10.4
作者：
Gaskin, Janet;Coyle, Doug;Krewksi, Daniel
通讯作者：
Krewksi, Daniel
影响因子：
1.5
作者：
Allodji, Rodrigue S.;Leuraud, Klervi;Laurier, Dominique
通讯作者：
Laurier, Dominique
影响因子：
3.4
作者：
Leuraud, Klervi;Schnelzer, Maria;Laurier, Dominique
通讯作者：
Laurier, Dominique
影响因子：
3.4
作者：
Hoffmann, Sabine;Rage, Estelle;Ancelet, Sophie
通讯作者：
Ancelet, Sophie