Association of socioeconomic status with iodine supply and thyroid disorders in northeast Germany.
Association of socioeconomic status with iodine supply and thyroid disorders in northeast Germany.
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德国东北部社会经济地位与碘供应和甲状腺疾病的关系
DOI：
10.1089/thy.2012.0416
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ittermann T
中科院分区：
文献类型：
--
作者：
Volzke H;Craesmeyer C;Nauck M;Below H;Kramer A;John U;Baumeister S;Ittermann T
目的：发达国家关于社会经济地位与碘供应和甲状腺疾病风险的潜在关联的研究很少。然而，社会经济状况可能特别影响以自愿原则为基础的碘预防计划的效率。本研究旨在调查德国东北部人群的社会经济状况是否与低尿排泄量或甲状腺疾病有关。方法：使用基于人群的波美拉尼亚健康研究数据。研究人群包括4056名成年人进行横断面分析和2860名成年人进行纵向分析。对社会经济地位的评估包括教育、收入、就业和职业的不同尺度。与甲状腺相关的结果包括尿碘排泄、血清促甲状腺激素以及超声确定的甲状腺肿大和结节。结果：在横断面分析中，一些社会经济变量与甲状腺相关特征有关。例如，总体上，受教育程度高、收入高的人群甲状腺体积更大，患甲状腺肿的风险也更高。然而，在对多次测试的目标值进行校正后，这些关联中的大多数都没有达到统计学意义。结论：社会经济状况对德国东北部成年人群的碘供应没有实质性影响，对甲状腺功能缺乏性疾病的患病率和发病率也没有重大影响，表明德国的强化碘计划在所有社会经济群体中都取得了良好的效果。
Objectives:Studies on the potential association of socioeconomic status with iodine supply and the risk for thyroid disorders from developed countries are sparse. Socioeconomic status, however, may particularly impact the efficiency of iodine prophylaxis programs, which are based on the voluntary principle. This study aims to investigate whether the socioeconomic status is cross-sectionally and longitudinally related to low urinary excretion or thyroid disorders in the population of northeast Germany.Methods:Data of the population-based Study of Health in Pomerania were used. The study population comprised 4056 adults for cross-sectional and 2860 adults for longitudinal analyses. Assessment of socioeconomic status comprised different scales of education, income, employment, and occupation. Thyroid-related outcomes included urinary iodine excretion, serum thyrotropin, and sonographically defined goiter and nodules. Statistical analyses were adjusted for confounders.Results:Some of the socioeconomic variables were associated with thyroid-related characteristics in cross-sectional analyses. For example, there was an overall tendency for groups with higher education and higher income to have larger thyroid volumes and an increased risk of goiter. However, most of these associations did not attain statistical significance after correcting the targetp-value for multiple testing. Longitudinal analyses did not demonstrate consistent results.Conclusions:Socioeconomic status neither substantially influences iodine supply nor does it have a major impact on the prevalence and incidence of thyroid deficiency–related disorders in the adult population of northeast Germany, indicating a good efficacy of the German iodine fortification program in all socioeconomic groups.
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DOI：
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发表时间：
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