Macaque monkey trigeminal blink reflex circuits targeting orbicularis oculi motoneurons.
Macaque monkey trigeminal blink reflex circuits targeting orbicularis oculi motoneurons.
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DOI：
10.1002/cne.25130
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发表时间：
2021-08-01
期刊：
影响因子：
--
通讯作者：
Warren S
中科院分区：
文献类型：
--
作者：
May PJ;Warren S
三叉神经瞬目反射在不可预测的环境中保护角膜表面免受损伤和维持视觉功能方面起着重要作用。由眼轮匝肌的激活产生的反射的闭合相由初始的、小的、同侧的R1分量和随后的较大的、双侧的R2分量组成。我们研究了电路，根据这种反射在猕猴（食蟹猴和mulatta）猴使用单和双示踪剂的方法。将逆行示踪剂注射到三叉神经主核的面神经核标记神经元中，以及双侧脊核口部和极间部中，以及同侧尾侧部中。将顺行示踪剂注入三叉神经主核标记的轴突直接终止于眼轮匝肌运动神经元，同侧优势。顺行示踪剂注入三叉神经脊束核尾侧部标记直接终止于同侧眼轮匝肌运动神经元的轴突。观察到的模式的标签表明，网状结构腹内侧的主要和脊髓核也有助于广泛的双边输入眼轮匝肌运动神经元。因此，三叉神经感觉复合体的大部分处于为眼睑闭合提供单突触驱动的位置，并且相邻的网状结构可以提供双突触驱动。这些研究结果表明，分配的R1和R2组件的眨眼反射三叉神经感觉复合体的不同部分不能完全基于细分与面部运动神经元的连接关系。R2组件的特性可能是由于其他电路特性。
The trigeminal blink reflex plays an important role in protecting the corneal surface from damage and preserving visual function in an unpredictable environment. The closing phase of the reflex, produced by activation of the orbicularis oculi muscles, consists of an initial, small, ipsilateral R1 component, followed by a larger, bilateral R2 component. We investigated the circuitry that underlies this reflex in macaque (Macaca fascicularis and mulatta) monkeys by use of single and dual tracer methods. Injection of retrograde tracer into the facial nucleus labeled neurons in the principal trigeminal nucleus, and in the spinal nucleus pars oralis and interpolaris, bilaterally, and in pars caudalis, ipsilaterally. Injection of anterograde tracer into the principal trigeminal nucleus labeled axons that directly terminated on orbicularis oculi motoneurons, with an ipsilateral predominance. Injection of anterograde tracer into pars caudalis of the spinal trigeminal nucleus labeled axons that directly terminated on ipsilateral orbicularis oculi motoneurons. The observed pattern of labeling indicates that the reticular formation ventromedial to the principal and spinal nuclei also contributes extensive bilateral input to orbicularis oculi motoneurons. Thus, much of the trigeminal sensory complex is in a position to supply monosynaptic drive for lid closure, and the adjacent reticular formation can supply a disynaptic drive. These findings indicate that assignment of the R1 and R2 components of the blink reflex to different parts of trigeminal sensory complex cannot be exclusively based on subdivision connectional relationships with facial motoneurons. The characteristics of the R2 component may be due, instead, to other circuit properties.
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DOI：
10.1016/0924-980x(96)95684-2
发表时间：
1996-08-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Ellrich, J;Hopf, HC
通讯作者：
Hopf, HC
影响因子：
2.5
作者：
Gruart, A;Schreurs, BG;Delgado-García, JM
通讯作者：
Delgado-García, JM
影响因子：
2.5
作者：
Hirata, H;Takeshita, S;Bereiter, DA
通讯作者：
Bereiter, DA
影响因子：
2.9
作者：
HOLSTEGE, G;VANHAM, JJ;TAN, J
通讯作者：
TAN, J
影响因子：
6.4
作者：
Cruz, Antonio A. V.;Garcia, Denny M.;Cechetti, Sheila P.
通讯作者：
Cechetti, Sheila P.