Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.
Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.
复制标题
早期抽动秽语综合征儿童自发大脑活动的改变：一项静息态功能磁共振成像研究
DOI：
10.1038/s41598-017-04148-z
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Peng Y
中科院分区：
文献类型：
--
作者：
Liu Y;Wang J;Zhang J;Wen H;Zhang Y;Kang H;Wang X;Li W;He H;Peng Y
多发性抽动症(TS)是一种儿童起病的慢性疾病，以多种运动和声带痉挛为特征。本研究采用静息功能磁共振成像技术，研究了TS患儿脑自发活动的变化。我们获得了21名药物天真和单纯的TS儿童和29名人口统计学上匹配的健康儿童的rS-fMRI扫描。计算rS-fMRI数据的低频波动幅度(Alff)、分数Alff(FALff)和区域均匀度(ReHo)以测量自发脑活动。我们在TS儿童的视觉相关结构中发现了Alff或fALFF的显著变化，包括双侧距骨沟、楔叶、梭形回和左脑岛。右侧小脑可见ReHO降低。进一步分析表明，右侧小脑的ReHO值与TS持续时间呈正相关。我们的研究为TS患者的神经元异常自发活动提供了经验证据，这可能涉及TS儿童的神经生理机制。此外，右侧小脑可以潜在地作为儿童早期TS的病理生理学的生物标志物。
Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naïve and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.7
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影响因子：
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Schlaggar, Bradley L.
影响因子：
1.9
作者：
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通讯作者：
Singer, Harvey S.
影响因子：
2.9
作者：
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