Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides.
Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides.
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DOI：
10.1016/j.ntt.2017.10.009
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发表时间：
2018-09
影响因子：
2.9
通讯作者：
Creton R
中科院分区：
文献类型：
--
作者：
Richendrfer H;Creton R
许多育龄妇女使用抗抑郁药。治疗可以在怀孕期间继续，因为未经治疗的抑郁症会对母亲和孩子造成风险。然而，许多抗抑郁药很容易通过胎盘屏障到达胎儿，或者可能通过母乳被新生儿摄入。关于抗抑郁药对幼儿大脑发育和随后行为的影响知之甚少。在当前的研究中，我们使用斑马鱼作为模型系统来检查三种常用抗抑郁药舍曲林、度洛西汀和安非他酮对神经发育的影响。斑马鱼在发育过程中暴露于这些抗抑郁药，并检查了幼虫回避行为，活动，社会行为和焦虑相关行为的变化。结果表明，抗抑郁药通常会影响幼虫的游泳速度和休息，并根据暴露时间的不同而不同地影响其他行为。使用聚类分析分析，我们比较了所获得的结果，以前的报告中的行为缺陷引起的有机磷农药。我们发现，抗抑郁药和杀虫剂诱导的行为特征重叠，表明共同的作用机制。我们的结论是，发育抗抑郁剂暴露导致特定的行为变化，斑马鱼幼虫。目前，尚不清楚抗抑郁药是否对人类发育有类似的影响。
Antidepressants are used by a substantial number of women in their childbearing years. Treatment may continue during pregnancy, since untreated depression poses a risk to the mother and child. However, many antidepressants readily pass through the placental barrier to reach the fetus or may be ingested by the newborn via breastmilk. Little is known about the effects of antidepressants on brain development and subsequent behavior in young children. In the current study, we used zebrafish as a model system to examine the neurodevelopmental effects of three commonly prescribed antidepressants, sertraline, duloxetine and bupropion. Zebrafish were exposed to these antidepressants during development and were examined for changes in larval avoidance behavior, activity, social behaviors, and anxiety-related behaviors. The results show that antidepressants commonly affect larval swim speeds and resting, and differentially affect other behaviors depending upon the exposure period. Using cluster analysis profiling, we compared the obtained results to previous reports on behavioral defects induced by organophosphate pesticides. We found that the behavioral profiles induced by antidepressants and pesticides overlap, indicating a common mechanism of action. We conclude that developmental antidepressant exposures lead to specific behavioral changes in zebrafish larvae. At present, it is not known if antidepressants have similar effects in human development.
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影响因子：
3.7
作者：
Cacialli P;Gueguen MM;Coumailleau P;D'Angelo L;Kah O;Lucini C;Pellegrini E
通讯作者：
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影响因子：
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1.3
作者：
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通讯作者：
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