Multifunctional Benefits of Prevalent HMOs: Implications for Infant Health.
Multifunctional Benefits of Prevalent HMOs: Implications for Infant Health.
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流行的HMO的多功能益处：对婴儿健康的影响。
DOI：
10.3390/nu13103364
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发表时间：
2021-09-25
期刊：
影响因子：
5.9
通讯作者：
Buck RH
中科院分区：
文献类型：
--
作者：
Hill DR;Chow JM;Buck RH
母乳喂养是婴儿期最好的营养来源，具有广泛的健康益处。然而，仍然存在对婴儿配方食品创新的显著和持续的需求，这些创新将允许婴儿获得母乳喂养的婴儿可获得的更广泛的益处。在婴儿配方奶粉中添加人乳低聚糖（HMO）是近年来婴儿营养领域最重大的创新。虽然HMO不是牛奶中卡路里的直接来源，但它是有效的益生元，多功能抗感染剂和神经认知发育的关键支持。食品科学的不断进步将在未来几年内促进各种HMO结构的生产。在这篇综述中，我们评估HMO结构和功能效益之间的关系。我们建议婴儿配方食品强化策略应旨在概括广泛的益处，以支持与母乳中HMO相关的消化健康，免疫力和认知发育。我们得出结论，乙酰化，岩藻糖基化和唾液酸化的HMO可能通过多种互补的作用机制赋予重要的健康益处。
Breastfeeding is the best source of nutrition during infancy and is associated with a broad range of health benefits. However, there remains a significant and persistent need for innovations in infant formula that will allow infants to access a wider spectrum of benefits available to breastfed infants. The addition of human milk oligosaccharides (HMOs) to infant formulas represents the most significant innovation in infant nutrition in recent years. Although not a direct source of calories in milk, HMOs serve as potent prebiotics, versatile anti-infective agents, and key support for neurocognitive development. Continuing improvements in food science will facilitate production of a wide range of HMO structures in the years to come. In this review, we evaluate the relationship between HMO structure and functional benefits. We propose that infant formula fortification strategies should aim to recapitulate a broad range of benefits to support digestive health, immunity, and cognitive development associated with HMOs in breastmilk. We conclude that acetylated, fucosylated, and sialylated HMOs likely confer important health benefits through multiple complementary mechanisms of action.
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影响因子：
4.3
作者：
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影响因子：
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