Application of Wastewater-Based Epidemiology for Tracking Human Exposure to Deoxynivalenol and Enniatins.
Application of Wastewater-Based Epidemiology for Tracking Human Exposure to Deoxynivalenol and Enniatins.
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DOI：
10.3390/toxins14020091
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发表时间：
2022-01-25
期刊：
影响因子：
4.2
通讯作者：
Bartkevics V
中科院分区：
文献类型：
--
作者：
Berzina Z;Pavlenko R;Jansons M;Bartkiene E;Neilands R;Pugajeva I;Bartkevics V
基于水的流行病学（WBE）是一种很有前途的生物监测方法，有可能提供有关人类摄入和暴露于食品污染物和环境化学品的直接信息。本研究的目的是应用WBE，同时采用归一化方法，根据人群生物标志物5-羟基吲哚乙酸（5-HIAA）探索人类暴露于选定的真菌毒素。这种类型的标准化技术以前曾用于检测各种其他化合物。然而，据我们所知，这是第一项跟踪人类暴露于真菌毒素的研究。开发了一种灵敏的分析方法，以实现废水（WW）样品中脱氧雪腐镰刀菌烯醇，恩镰孢菌素，白僵菌素的可靠定量。该方法的适用性进行了评估，通过测试29 WW样品收集在WW处理厂在拉脱维亚。检测频率大于86%，在WW样品中发现恩镰孢菌素B、B1、A和A1。恩格列汀的估计每日总摄入量为每人1.8 - 27.6 µ g/天。在所有分析的WW样品中测定游离脱氧雪腐镰刀菌烯醇（DON）。根据平均5-HIAA排泄水平和样品中测定的5-HIAA含量，估计里加人群的DON摄入量为325 ng/kg b.w.。天
Wastewater-based epidemiology (WBE) is a promising biomonitoring approach with the potential to provide direct information on human intake and exposure to food contaminants and environmental chemicals. The aim of this study was to apply WBE while employing the normalization method for exploring human exposure to selected mycotoxins according to population biomarker 5-hydroxyindoleacetic acid (5-HIAA). This type of normalization technique has been previously used to detect various other compounds. However, to the best of our knowledge, this is the first study tracking human exposure to mycotoxins. A sensitive analytical methodology was developed to achieve reliable quantification of deoxynivalenol, enniatins, and beauvericin in wastewater (WW) samples. The applicability of the method was evaluated by testing 29 WW samples collected at WW treatment plants in Latvia. With frequency of detection greater than 86%, enniatins B, B1, A, and A1 were revealed in WW samples. The estimated total daily intake for enniatins was in the range of 1.8–27.6 µg/day per person. Free deoxynivalenol (DON) was determined in all analysed WW samples. Based on the average 5-HIAA excretion level and the determined 5-HIAA content in the samples, the intake of DON by the human population of Riga was estimated at 325 ng/kg b.w. day.
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影响因子：
9.8
作者：
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