Heterogeneity of the left temporal lobe in semantic representation and control: priming multiple versus single meanings of ambiguous words.
Heterogeneity of the left temporal lobe in semantic representation and control: priming multiple versus single meanings of ambiguous words.
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DOI：
10.1093/cercor/bhq148
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Kircher T
中科院分区：
文献类型：
--
作者：
Whitney C;Jefferies E;Kircher T
语义判断包括意义的表征和以任务适当的方式引导知识检索的执行机制。语义认知的这两个组成部分表征和控制通常分别与左颞叶和前额叶皮层有关。然而，这个简单的提议仍然存在争议，因为在迄今为止的大多数功能性神经影像学研究中，被激活的概念的数量和提取过程中执行过程的参与是混淆的。使用功能磁共振成像，我们研究了一个任务中，语义表征和控制要求是分离的。在双启动范式中，以“bank”等具有多重意义的词为目标，将多重意义激活和最大执行要求加载到不同的启动条件下。前下颞回（ITG）是敏感的检索的含义的数量，这表明该地区的语义表征的作用，而后中颞回（pMTG）和额叶皮层下表现出更大的激活条件，最大限度地提高执行要求。这些结果支持左ITG和pMTG之间的功能分离，符合修订后的神经组织中，左前额叶和后颞区一起工作，以支持方面的语义控制。
Semantic judgments involve both representations of meaning plus executive mechanisms that guide knowledge retrieval in a task-appropriate way. These 2 components of semantic cognition—representation and control—are commonly linked to left temporal and prefrontal cortex, respectively. This simple proposal, however, remains contentious because in most functional neuroimaging studies to date, the number of concepts being activated and the involvement of executive processes during retrieval are confounded. Using functional magnetic resonance imaging, we examined a task in which semantic representation and control demands were dissociable. Words with multiple meanings like “bank” served as targets in a double-prime paradigm, in which multiple meaning activation and maximal executive demands loaded onto different priming conditions. Anterior inferior temporal gyrus (ITG) was sensitive to the number of meanings that were retrieved, suggesting a role for this region in semantic representation, while posterior middle temporal gyrus (pMTG) and inferior frontal cortex showed greater activation in conditions that maximized executive demands. These results support a functional dissociation between left ITG and pMTG, consistent with a revised neural organization in which left prefrontal and posterior temporal areas work together to underpin aspects of semantic control.
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