MR spectroscopy of normative premature newborns.

MR spectroscopy of normative premature newborns.
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DOI:
10.1002/jmri.22460
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发表时间:
2011-02
影响因子:
4.4
通讯作者:
Barkovich, A. James
Barkovich, A. James
中科院分区:
医学2区
文献类型:
--
作者:
Xu, Duan;Bonifacio, Sonia L.;Charlton, Natalie N.;Vaughan, Charles P.;Lu, Ying;Ferriero, Donna M.;Vigneron, Daniel B.;Barkovich, A. James

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使用3D磁共振光谱成像技术在整个新生儿大脑中建立标准的代谢物比例。MRI和MRSI是评估新生儿正常和异常神经元成熟的有价值的工具。在这项研究中,我们除了进行全面的解剖和其他功能成像方法外,还进行了全脑3D磁共振成像以检查成熟度。55名新生儿(出生时28.4±2.6周,扫描时34.1±3.1周,男性32例,女性23例)在12个月时有高质量的MRSI检查(104次)和正常的神经发育结果(NMS=0,MDI和GT;85)。在所有地区,NAA/CHO比率随着年龄的增长而显著增加。在丘脑、基底节、皮质脊髓束、顶叶白质等部位,Lac/NAA比值随年龄增长而显著降低,其他部位则呈下降趋势。脑代谢产物可以通过活体3D MRSI获得,并用于监测新生儿大脑的成熟。
To establish normative metabolite ratios throughout the newborn brain using 3D MR Spectroscopic Imaging. MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. 55 newborn subjects (28.4 ± 2.6 weeks post-conceptional age at birth, 34.1 ± 3.1 weeks post-conception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (NMS=0, MDI>85) at age 12 months. The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions. Brain metabolites can be obtained through in vivo 3D MRSI and used to monitor newborn brain maturation.
DOI: 10.1148/radiology.194.2.7529934
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期刊: RADIOLOGY
影响因子: 19.7
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