MR spectroscopy of normative premature newborns.
MR spectroscopy of normative premature newborns.
复制标题
DOI:
10.1002/jmri.22460
复制
发表时间:
2011-02
影响因子:
4.4
通讯作者:
Barkovich, A. James
中科院分区:
文献类型:
--
作者:
Xu, Duan;Bonifacio, Sonia L.;Charlton, Natalie N.;Vaughan, Charles P.;Lu, Ying;Ferriero, Donna M.;Vigneron, Daniel B.;Barkovich, A. James
To establish normative metabolite ratios throughout the newborn brain using 3D MR Spectroscopic Imaging. MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. 55 newborn subjects (28.4 ± 2.6 weeks post-conceptional age at birth, 34.1 ± 3.1 weeks post-conception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (NMS=0, MDI>85) at age 12 months. The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions. Brain metabolites can be obtained through in vivo 3D MRSI and used to monitor newborn brain maturation.
登录
查看更多内容
影响因子:
19.7
作者:
KIMURA, H;FUJII, Y;ISHII, Y
通讯作者:
ISHII, Y
影响因子:
3.3
作者:
Kreis, R;Hofmann, L;Hüppi, PS
通讯作者:
Hüppi, PS
影响因子:
3.5
作者:
Bartha, A. L.;Yap, K. R. L.;Ferriero, D. M.
通讯作者:
Ferriero, D. M.
影响因子:
3.3
作者:
Nelson, SJ
通讯作者:
Nelson, SJ
影响因子:
3.3
作者:
Fan, GG;Wu, ZH;Mao, J
通讯作者:
Mao, J