Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.
Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.
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DOI：
10.1186/s13071-021-05132-3
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发表时间：
2022-03-31
影响因子：
3.2
通讯作者：
Mello CB
中科院分区：
文献类型：
--
作者：
Ratcliffe NA;Furtado Pacheco JP;Dyson P;Castro HC;Gonzalez MS;Azambuja P;Mello CB
本文综述了利用昆虫介导的副转基因控制病原体传播的研究进展。它首先简要总结了一些由昆虫传播的致病病原体，并强调需要创新的控制方法来应对媒介昆虫对杀虫剂和病原体对治疗药物的抗药性威胁。随后，国家的艺术parattransgenesis的描述，这是一个特别巧妙的方法，目前正在开发中的许多重要的媒介昆虫，可以提供一个额外的强大的工具，用于综合虫害防治方案。详细介绍了副转基因技术的要求和最新进展，并概述了用于遗传修饰的微生物的选择、待表达的效应分子以及转基因细菌在野生昆虫种群中的环境传播。本文分析了锥蝽、蚊、白蛉和采采蝇的副转殖实验模型的结果。最后，监管和安全规则，以满足成功的环境释放的基因工程生物产生的副transgenesis考虑。
This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.
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影响因子：
3.8
作者：
Aksoy S;Buscher P;Lehane M;Solano P;Van Den Abbeele J
通讯作者：
Van Den Abbeele J
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DOI：
10.1016/j.cgh.2018.09.017
发表时间：
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期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
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作者：
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3.2
作者：
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
3.5
作者：
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