Early ethanol and water intake: choice mechanism and total fluid regulation operate in parallel in male alcohol preferring (P) and both Wistar and Sprague Dawley rats.
Early ethanol and water intake: choice mechanism and total fluid regulation operate in parallel in male alcohol preferring (P) and both Wistar and Sprague Dawley rats.
复制标题
DOI：
10.1016/j.physbeh.2013.09.011
复制
发表时间：
2014-01-17
影响因子：
2.9
通讯作者：
Woodward DJ
中科院分区：
文献类型：
--
作者：
Azarov AV;Woodward DJ
本研究的目的是澄清在酒精偏好p大鼠与非选择Wistar和Sprague Dawley （SD）大鼠在酒精和水选择饮酒的早期阶段的液体摄入相似和明显不同的参数。需要精确的饮酒量和时间信息来分析乙醇摄入获取的微观行为成分，并能够在单个中枢神经系统回路中搜索其因果活动模式。实验遵循p大鼠选择育种中使用的标准乙醇饮用试验，首先获得水，然后10%乙醇（10E）作为唯一液体，其次是乙醇/水选择。当前方法的新颖之处在于，通过将日常食物与液体摄入时间分开，消除了膳食中液体摄入的混淆性升高。与Wistar和SD大鼠相比，P大鼠初始水和10E作为唯一液体的摄入量较高，表明P大鼠对乙醇引起的脱水有适应性。p -大鼠在选择期的起始和总乙醇摄入量最高。选择期乙醇摄入量绝对升高幅度在Wistar中最大，其最终摄入水平接近p大鼠，这与选择期乙醇摄入量升高幅度最大的假设相反。在乙醇/水选择期间，P大鼠、Wistar大鼠和SD大鼠的日总液体量惊人相似。这支持了一个通用系统的假设，该系统通过滴定和整合乙醇和水的饮用波动来测量总摄入量，并表明在选择条件下，三种线的液体摄入量的主要调节参数是稳定的每日总液体水平。目前的研究结果表明，稳定的每日总液体水平包括每日乙醇摄入量的独立生理极限。酒精饮用，反过来，在乙醇/水选择的平行机制的驱动下，保持在这个限制的上限之下。
The goal of this study was to clarify similar and distinctly different parameters of fluid intake during early phases of ethanol and water choice drinking in alcohol preferring P-rat vs. non-selected Wistar and Sprague Dawley (SD) rats. Precision information on the drinking amounts and timing is needed to analyze micro-behavioral components of the acquisition of ethanol intake and to enable a search for its causal activity patterns within individual CNS circuits. The experiment followed the standard ethanol-drinking test used in P-rat selective breeding, with access to water, then 10% ethanol (10E) as sole fluids, and next to ethanol / water choice. The novelty of the present approach was to eliminate confounding prandial elevations of fluid intake, by time-separating daily food from fluid access. P-rat higher initial intakes of water and 10E as sole fluids suggest adaptations to ethanol-induced dehydration in P vs. Wistar and SD rats. P-rat starting and overall ethanol intake during the choice period were the highest. The absolute extent of ethanol intake elevation during choice period was greatest in Wistar and their final intake levels approached those of P-rat, contrary to the hypothesis that selection would produce the strongest elevation of ethanol intake. The total daily fluid during ethanol / water choice period was strikingly similar between P, Wistar and SD rats. This supports the hypothesis for a universal system that gauges the overall intake volume by titrating and integrating ethanol and water drinking fluctuations, and indicates a stable daily level of total fluid as a main regulated parameter of fluid intake across the three lines in choice conditions. The present findings indicate that a stable daily level of total fluid comprises an independent physiological limit for daily ethanol intake. Ethanol drinking, in turn, stays under the ceiling of this limit, driven by a parallel mechanism of ethanol / water choice.
登录
查看更多内容
DOI：
10.1037/h0026772
发表时间：
1969-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
FITZSIMO.JT;LEMAGNEN, J
通讯作者：
LEMAGNEN, J
影响因子：
3.6
作者：
Bell, Richard L.;Sable, Helen J. K.;Colombo, Giancarlo;Hyytia, Petri;Rodd, Zachary A.;Lumeng, Lawrence
通讯作者：
Lumeng, Lawrence
影响因子：
5.8
作者：
ERIKSSON, CJP;SIPPEL, HW
通讯作者：
SIPPEL, HW
影响因子：
2.9
作者：
Guccione, Lisa;Djouma, Elvan;Paolini, Antonio G.
通讯作者：
Paolini, Antonio G.
DOI：
10.1037/h0026773
发表时间：
1969-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
KISSILEFF, HR
通讯作者：
KISSILEFF, HR