Associations of long-term fine particulate matter exposure with prevalent hypertension and increased blood pressure in older Americans.
Associations of long-term fine particulate matter exposure with prevalent hypertension and increased blood pressure in older Americans.
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DOI：
10.1016/j.envres.2018.02.008
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发表时间：
2018-07
影响因子：
8.3
通讯作者：
Suh H
中科院分区：
文献类型：
--
作者：
Honda T;Pun VC;Manjourides J;Suh H
高血压是一种非常普遍的心血管危险因素。空气污染也是一个确定的心血管危险因素，有可能通过血压升高导致心血管疾病。之前评估空气污染和血压之间关系的研究得出了不同的结果。我们研究了4121名美国老年人（57岁以上）参加国家社会生活、健康和老龄化项目的长期（一年移动平均）空气污染物暴露与高血压和血压之间的关系。我们使用时空模型估计PM2.5暴露，并使用logistic回归计算重复测量来评估长期平均PM2.5与高血压患病率之间的关系。我们还使用线性回归来评估空气污染物与收缩压、舒张压、平均动脉压和脉压之间的关系。健康效应模型根据一些人口统计学、健康和社会经济协变量进行了调整。PM2.5一年移动平均值的四分位数范围（3.91µg/m3）增加与：高血压（POR 1.24, 95% CI: 1.11, 1.38）、收缩压（0.93 mm Hg, 95% CI: 0.05, 1.80）和脉压（0.89 mm Hg, 95% CI: 0.21, 1.58）的几率增加相关。剂量-反应关系也被观察到。在一组美国老年人中，PM2.5与高血压患病率增加、收缩压和脉压升高有关。越来越多的证据表明，空气污染可能是高血压和血压紊乱的一个重要危险因素，这些发现进一步证明了这一点。
Hypertension is a highly prevalent cardiovascular risk factor. It is possible that air pollution, also an established cardiovascular risk factor, may contribute to cardiovascular disease through increasing blood pressure. Previous studies evaluating associations between air pollution and blood pressure have had mixed results. We examined the association between long-term (one-year moving average) air pollutant exposures, prevalent hypertension and blood pressure in 4,121 older Americans (57+ years) enrolled in the National Social Life, Health, and Aging Project. We estimated exposures to PM2.5 using spatio-temporal models and used logistic regression accounting for repeated measures to evaluate the association between long-term average PM2.5 and prevalence odds of hypertension. We additionally used linear regression to evaluate the associations between air pollutants and systolic, diastolic, mean arterial, and pulse pressures. Health effect models were adjusted for a number of demographic, health and socioeconomic covariates. An inter-quartile range (3.91 µg/m3) increase in the one-year moving average of PM2.5 was associated with increased: Odds of prevalent hypertension (POR 1.24, 95% CI: 1.11, 1.38), systolic blood pressure (0.93 mm Hg, 95% CI: 0.05, 1.80) and pulse pressure (0.89 mm Hg, 95% CI: 0.21, 1.58). Dose-response relationships were also observed. PM2.5 was associated with increased odds of prevalent hypertension, and increased systolic pressure and pulse pressure in a cohort of older Americans. These findings add to the growing evidence that air pollution may be an important risk factor for hypertension and perturbations in blood pressure.
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影响因子：
10.4
作者：
Babisch W;Wolf K;Petz M;Heinrich J;Cyrys J;Peters A
通讯作者：
Peters A
影响因子：
10.4
作者：
Fuks KB;Weinmayr G;Foraster M;Dratva J;Hampel R;Houthuijs D;Oftedal B;Oudin A;Panasevich S;Penell J;Sommar JN;Sørensen M;Tiittanen P;Wolf K;Xun WW;Aguilera I;Basagaña X;Beelen R;Bots ML;Brunekreef B;Bueno-de-Mesquita HB;Caracciolo B;Cirach M;de Faire U;de Nazelle A;Eeftens M;Elosua R;Erbel R;Forsberg B;Fratiglioni L;Gaspoz JM;Hilding A;Jula A;Korek M;Krämer U;Künzli N;Lanki T;Leander K;Magnusson PK;Marrugat J;Nieuwenhuijsen MJ;Ostenson CG;Pedersen NL;Pershagen G;Phuleria HC;Probst-Hensch NM;Raaschou-Nielsen O;Schaffner E;Schikowski T;Schindler C;Schwarze PE;Søgaard AJ;Sugiri D;Swart WJ;Tsai MY;Turunen AW;Vineis P;Peters A;Hoffmann B
通讯作者：
Hoffmann B
影响因子：
37.8
作者：
Chen, Hong;Burnett, Richard T.;Copes, Ray
通讯作者：
Copes, Ray
影响因子：
10.4
作者：
Chan SH;Van Hee VC;Bergen S;Szpiro AA;DeRoo LA;London SJ;Marshall JD;Kaufman JD;Sandler DP
通讯作者：
Sandler DP
影响因子：
120.7
作者：
KANNEL, WB;WOLF, PA;CASTELLI, WP
通讯作者：
CASTELLI, WP