The tactile experience paired with vagus nerve stimulation determines the degree of sensory recovery after chronic nerve damage.
The tactile experience paired with vagus nerve stimulation determines the degree of sensory recovery after chronic nerve damage.
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DOI：
10.1016/j.bbr.2020.112910
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发表时间：
2021-01-01
影响因子：
2.7
通讯作者：
Kilgard MP
中科院分区：
文献类型：
--
作者：
Darrow MJ;Mian TM;Torres M;Haider Z;Danaphongse T;Seyedahmadi A;Rennaker RL 2nd;Hays SA;Kilgard MP
感觉功能丧失是神经损伤的常见后果。最近的临床和临床前证据表明，迷走神经刺激（VNS）与触觉康复配对，包括传递各种机械刺激到低敏皮肤表面，产生实质性和持久的恢复后，正中神经和尺神经横断和修复的躯体感觉功能。在这里，我们测试的假设，一个特定的组成部分，触觉康复配对VNS是必要的躯体感觉功能的恢复。在第二个实验中，在一个单独的队列，我们调查是否VNS配对触觉康复可以提高熟练的前肢运动功能。在开始数据收集之前，预先登记研究设计要素，包括计划的样本量、评估和统计比较（https：//osf.io/3tm8u/）。动物接受外周神经损伤（PNI），导致慢性感觉丧失。损伤后8周，动物给予VNS植入物，随后进行6周的触觉康复训练，包括重复应用两种不同的机械刺激之一，细丝或画笔，到先前失神经支配的前爪。与无VNS的触觉康复相比，与细丝压痕或刷爪配对的VNS显著改善了PNI后前肢缩回阈值的恢复。当VNS与刷牙配对时，效果大小是VNS与点压痕配对时的两倍。在第二个队列中的独立复制证实，VNS与刷配对恢复前肢退缩阈值正常。与未接受VNS的大鼠相比，这些大鼠在熟练的前肢任务上表现出显着的改善。这些研究结果支持的效用配对VNS触觉康复，以改善恢复后的躯体感觉和运动功能的神经损伤。此外，这项研究表明，与VNS配对的康复的感觉特征决定了恢复的程度。
Loss of sensory function is a common consequence of neurological injury. Recent clinical and preclinical evidence indicates vagus nerve stimulation (VNS) paired with tactile rehabilitation, consisting of delivery of a variety of mechanical stimuli to the hyposensitive skin surface, yields substantial and long-lasting recovery of somatosensory function after median and ulnar nerve transection and repair. Here, we tested the hypothesis that a specific component of the tactile rehabilitation paired with VNS is necessary for recovery of somatosensory function. In a second experiment in a separate cohort, we investigated whether VNS paired with tactile rehabilitation could improve skilled forelimb motor function. Elements of the study design, including planned sample size, assessments, and statistical comparisons, were preregistered prior to beginning data collection (https://osf.io/3tm8u/). Animals received a peripheral nerve injury (PNI) causing chronic sensory loss. Eight weeks after injury, animals were given a VNS implant followed by six weeks of tactile rehabilitation sessions consisting of repeated application of one of two distinct mechanical stimuli, a filament or a paintbrush, to the previously denervated forepaw. VNS paired with either filament indentation or brushing of the paw significantly improved recovery of forelimb withdrawal thresholds after PNI compared to tactile rehabilitation without VNS. The effect size was twice as large when VNS was paired with brushing compared to VNS paired with point indentation. An independent replication in a second cohort confirmed that VNS paired with brush restored forelimb withdrawal thresholds to normal. These rats displayed significant improvements in performance on a skilled forelimb task compared to rats that did not receive VNS. These findings support the utility of pairing VNS with tactile rehabilitation to improve recovery of somatosensory and motor function after neurological injury. Additionally, this study demonstrates that the sensory characteristics of the rehabilitation paired with VNS determine the degree of recovery.
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影响因子：
4.2
作者：
Byl, N;Roderick, J;Abrams, G
通讯作者：
Abrams, G
影响因子：
4.2
作者：
Hays SA;Ruiz A;Bethea T;Khodaparast N;Carmel JB;Rennaker RL 2nd;Kilgard MP
通讯作者：
Kilgard MP
影响因子：
5.3
作者：
Hulsey DR;Riley JR;Loerwald KW;Rennaker RL 2nd;Kilgard MP;Hays SA
通讯作者：
Hays SA
影响因子：
3.8
作者：
Galtrey, Clare M.;Fawcett, James W.
通讯作者：
Fawcett, James W.
影响因子：
2.6
作者：
Elliott, Robert E.;Morsi, Amr;Doyle, Werner K.
通讯作者：
Doyle, Werner K.