Sex-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS).
Sex-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS).
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DOI：
10.1016/j.biopsycho.2010.02.012
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发表时间：
2010-05
影响因子：
2.6
通讯作者：
Naliboff, B. D.
中科院分区：
文献类型：
--
作者：
Kilpatrick, L. A.;Ornitz, E.;Ibrahimovic, H.;Treanor, M.;Craske, M.;Nazarian, M.;Labus, J. S.;Mayer, E. A.;Naliboff, B. D.
关键词：
Alterations in central networks involved in regulation of arousal, attention, and cognition may be critical for IBS symptom maintenance and exacerbation. Differential sensitivities in these networks may underlie sex differences noted in IBS. The current study examined prepulse inhibition (PPI), a measure of sensorimotor gating, in male and female IBS patients. Relationships between PPI and symptom severity were examined, as well as potential menstrual status effects. Compared to healthy controls, male IBS patients had significantly reduced PPI; whereas female IBS patients (particularly naturally cycling women) had significantly enhanced PPI suggesting hypervigilance. Considering previously demonstrated sex-related differences in perceptual and brain imaging findings in IBS patients, the current findings suggest different neurobiological mechanisms underlie symptom presentation in male and female IBS patients. Compromised filtering of information in male IBS patients may be due to compromised top down (prefrontal, midcingulate) control mechanisms while increased attention to threat due to increased limbic and paralimbic circuits may be characteristic of female IBS patients.
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影响因子：
3.7
作者：
Bagiella, E;Sloan, RP;Heitjan, DF
通讯作者：
Heitjan, DF
影响因子：
2.5
作者：
Heitkemper, Margaret;Jarrett, Monica;Chang, Lin
通讯作者：
Chang, Lin
影响因子：
9.8
作者：
Berman, SM;Naliboff, BD;Mayer, EA
通讯作者：
Mayer, EA
DOI：
10.1152/ajpregu.00065.2006
发表时间：
2006-08-01
影响因子：
2.8
作者：
Berman, Steven M.;Naliboff, Bruce D.;Mayer, Emeran A.
通讯作者：
Mayer, Emeran A.
DOI：
10.1152/ajpregu.00729.2005
发表时间：
2006-08-01
影响因子：
2.8
作者：
Chang, Lin;Mayer, Emeran A.;Naliboff, Bruce D.
通讯作者：
Naliboff, Bruce D.