Low-frequency stimulation of the hippocampal CA3 subfield is anti-epileptogenic and anti-ictogenic in rat amygdaloid kindling model of epilepsy
Low-frequency stimulation of the hippocampal CA3 subfield is anti-epileptogenic and anti-ictogenic in rat amygdaloid kindling model of epilepsy
复制标题
低频刺激海马 CA3 亚区在大鼠杏仁核点火模型中具有抗癫痫和抗癫痫作用
DOI：
10.1016/j.neulet.2009.03.041
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发表时间：
2009-05
影响因子：
2.5
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Chen Z;Zhong K;Zhang SH;Sun HL;WU DC;Fang Q;Wang S
用低频刺激（LFS）对癫痫灶以外的脑结构进行神经调节，可有效抑制动物和患者的癫痫发作，而LFS靶点的选择需要进一步研究。海马CA 3区是癫痫发作发生和传播回路的关键部位。本研究旨在探讨海马CA 3区LFS对大鼠杏仁核点燃癫痫发作获得和泛化的影响。我们发现，CA_3区的LFS（单相方波脉冲，1Hz，100μA，0.1ms/脉冲）通过延迟局灶性发作向全身性发作（GS）的进展，显著降低了癫痫样活动和发作获得的持续时间。此外，GS持续时间显着缩短，其潜伏期显着增加，在LFS组证明GS的严重程度和癫痫样活动的蔓延的抑制。此外，LFS还能阻止后放电阈值（ADT）的下降和GS阈值的升高，表明LFS对GS敏感性有抑制作用。提示海马CA 3区LFS具有抗癫痫和抗癫痫发作的作用。利用LFS神经调节CA 3活性可能是治疗颞叶癫痫的另一种潜在方法。
Neuromodulation with low-frequency stimulation (LFS), of brain structures other than epileptic foci, is effective in inhibiting seizures in animals and patients, whereas selection of targets for LFS requires further investigation. The hippocampal CA3subfield is a key site in the circuit of seizure generation and propagation. The present study aimed to illustrate the effects of LFS of the CA3region on seizure acquisition and generalization in the rat amygdaloid kindling model of epilepsy. We found that LFS (monophasic square-wave pulses, 1Hz, 100μA and 0.1ms per pulse) of the CA3region significantly depressed the duration of epileptiform activity and seizure acquisition by retarding progression from focal to generalized seizures (GS). Moreover, GS duration was significantly shortened and its latency was significantly increased in the LFS group demonstrating an inhibition of the severity of GS and the spread of epileptiform activity. Furthermore, LFS prevented the decline of afterdischarge threshold (ADT) and elevated GS threshold indicating an inhibition of susceptibility to GS. These results suggest that LFS of the hippocampal CA3subfield is anti-epileptogenic and anti-ictogenic. Neuromodulation of CA3activity using LFS may be an alternative potential approach for temporal lobe epilepsy treatment.
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影响因子：
56.9
作者：
Kobayashi, K;Manabe, T;Takahashi, T
通讯作者：
Takahashi, T
单侧低频刺激中央梨状皮层可延缓杏仁核点燃引起的大鼠癫痫发作
影响因子：
3.3
作者：
通讯作者：
--
影响因子：
6.1
作者：
Derchansky, M.;Rokni, D.;Carlen, P. L.
通讯作者：
Carlen, P. L.
影响因子：
6.1
作者：
Deng-chang Wu;Zhenghao Xu;Shuang Wang;Qi Fang;Danqing Hu;Qing Li;Hong-Liu Sun;Shihong Zhang
通讯作者：
Deng-chang Wu;Zhenghao Xu;Shuang Wang;Qi Fang;Danqing Hu;Qing Li;Hong-Liu Sun;Shihong Zhang
DOI：
10.1017/cbo9780511663314.007
发表时间：
1993
期刊：
--
影响因子：
--
作者：
S. Moshé;P. Stanton;E. Sperber
通讯作者：
S. Moshé;P. Stanton;E. Sperber