Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.
Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.
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DOI：
10.1016/j.celrep.2022.110620
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发表时间：
2022-04-05
期刊：
影响因子：
8.8
通讯作者：
Van Doren, Mark
中科院分区：
文献类型：
--
作者：
Bhaskar, Pradeep Kumar;Southard, Sheryl;Baxter, Kelly;Van Doren, Mark
生殖细胞性别的确定对于雌雄生殖系干细胞的发育和精子或卵子的产生至关重要。生殖细胞依靠来自体细胞性腺的信号来决定性别，但在苍蝇、老鼠和人类等生物中，生殖细胞的性染色体基因型对种系性发育也很重要。因此，体细胞信号和生殖细胞内在信号如何结合起来调节生殖细胞的性别决定是一个关键问题。我们发现GSC生态位中的JAK/STAT信号通过激活染色质读取器Phf7来促进生殖细胞中的男性身份。此外，我们发现JAK/STAT信号在XX（雌性）生殖细胞中通过性别决定基因的作用被阻断，以保持雌性身份。因此，种系性别身份的一个重要功能是控制GSCs如何响应其生态位环境中的信号。Bhaskar等人表明，生殖系性别身份控制着生殖系干细胞如何对其生态位环境中的信号做出反应。JAK/STAT信号通过激活染色质因子Phf7促进雄性生殖系性别认同，而Sxl在雌性生殖细胞中阻断JAK/STAT信号并维持雌性身份。
Establishing germ cell sexual identity is critical for development of male and female germline stem cells (GSCs) and production of sperm or eggs. Germ cells depend on signals from the somatic gonad to determine sex, but in organisms such as flies, mice, and humans, the sex chromosome genotype of the germ cells is also important for germline sexual development. How somatic signals and germ-cell-intrinsic cues combine to regulate germline sex determination is thus a key question. We find that JAK/STAT signaling in the GSC niche promotes male identity in germ cells, in part by activating the chromatin reader Phf7. Further, we find that JAK/STAT signaling is blocked in XX (female) germ cells through the action of the sex determination gene Sex lethal to preserve female identity. Thus, an important function of germline sexual identity is to control how GSCs respond to signals in their niche environment. Bhaskar et al. show that germline sexual identity controls how germline stem cells respond to signals in their niche environment. JAK/STAT signaling promotes male germline sexual identity by activating the chromatin factor Phf7, and Sxl acts in female germ cells to block JAK/STAT signaling and preserve female identity.
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影响因子：
7.7
作者：
Chen C;Cummings R;Mordovanakis A;Hunt AJ;Mayer M;Sept D;Yamashita YM
通讯作者：
Yamashita YM
影响因子：
14.9
作者：
Contrino S;Smith RN;Butano D;Carr A;Hu F;Lyne R;Rutherford K;Kalderimis A;Sullivan J;Carbon S;Kephart ET;Lloyd P;Stinson EO;Washington NL;Perry MD;Ruzanov P;Zha Z;Lewis SE;Stein LD;Micklem G
通讯作者：
Micklem G
影响因子：
64.5
作者：
Bashaw, GJ;Baker, BS
通讯作者：
Baker, BS
影响因子：
2.7
作者：
Ekas LA;Cardozo TJ;Flaherty MS;McMillan EA;Gonsalves FC;Bach EA
通讯作者：
Bach EA
DOI：
10.1007/bf00279527
发表时间：
1993-04-01
期刊：
MOLECULAR & GENERAL GENETICS
影响因子：
--
作者：
HANRATTY, WP;DEAROLF, CR
通讯作者：
DEAROLF, CR