Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis.
Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis.
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DOI：
10.1186/1471-2474-7-98
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发表时间：
2006-12-07
影响因子：
2.3
通讯作者：
Saxne T
中科院分区：
文献类型：
--
作者：
Andersson ML;Thorstensson CA;Roos EM;Petersson IF;Heinegård D;Saxne T
COMP（软骨寡聚基质蛋白）是一种基质蛋白，目前正在研究作为骨关节炎（OA）软骨过程的潜在血清标志物。体育锻炼对血清COMP的影响尚未完全阐明。本研究的目的是在一项随机对照试验中，对有症状和放射学检查的膝关节 OA 患者进行体育锻炼与标准化休息，监测 COMP 的血清水平。在运动或休息前后的预定时间点，从 58 名个体（一组为训练组，另一组为对照组）采集血样。体育锻炼包括每周两次每次一小时的监督训练和每天的家庭锻炼。在第二项补充研究中，7名受试者接受相同的运动计划，在运动前、运动后即刻、运动后30分钟和60分钟内每隔固定时间间隔进行一次血液采样，然后在运动后5小时内每隔60分钟采样一次，以监测血清COMP的短期变化。 COMP 采用夹心 ELISA（AnaMar Medical，Lund，瑞典）进行定量。运动前或休息前，各组间 COMP 水平没有显着差异。运动 60 分钟后，血清 COMP 水平升高 (p < 0.001)。休息 60 分钟后，血清水平下降 (p = 0.003)。在基线运动或休息前以及 24 周后获得的样本中，血清 COMP 中值值在研究开始和结束之间没有变化。在第二项研究中，运动后血清 COMP 立即升高（p = 0.018），30 分钟后降至基线水平。膝关节 OA 患者的血清 COMP 水平在运动期间升高，而在休息期间降低。运动后 30 分钟，升高的血清 COMP 水平恢复正常，因此我们建议在坐姿休息至少 30 分钟后抽取用于血清 COMP 分析的血液样本。六周的锻炼计划后没有看到任何增加，这表明个性化监督锻炼对软骨更新的任何影响都是短暂的。
COMP (Cartilage oligomeric matrix protein) is a matrix protein, which is currently studied as a potential serum marker for cartilage processes in osteoarthritis (OA). The influence of physical exercise on serum COMP is not fully elucidated. The objective of the present study was to monitor serum levels of COMP during a randomised controlled trial of physical exercise vs. standardised rest in individuals with symptomatic and radiographic knee OA. Blood samples were collected from 58 individuals at predefined time points before and after exercise or rest, one training group and one control group. The physical exercise consisted of a one-hour supervised session twice a week and daily home exercises. In a second supplementary study 7 individuals were subjected to the same exercise program and sampling of blood was performed at fixed intervals before, immediately after, 30 and 60 minutes after the exercise session and then with 60 minutes interval for another five hours after exercise to monitor the short-term changes of serum COMP. COMP was quantified with a sandwich-ELISA (AnaMar Medical, Lund, Sweden). Before exercise or rest no significant differences in COMP levels were seen between the groups. After 60 minutes exercise serum COMP levels increased (p < 0.001). After 60 minutes of rest the serum levels decreased (p = 0.003). Median serum COMP values in samples obtained prior to exercise or rest at baseline and after 24 weeks did not change between start and end of the study. In the second study serum COMP was increased immediately after exercise (p = 0.018) and had decreased to baseline levels after 30 minutes. Serum COMP levels increased during exercise in individuals with knee OA, whereas levels decreased during rest. The increased serum COMP levels were normalized 30 minutes after exercise session, therefore we suggest that samples of blood for analysis of serum COMP should be drawn after at least 30 minutes rest in a seated position. No increase was seen after a six-week exercise program indicating that any effect of individualized supervised exercise on cartilage turnover is transient.
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影响因子：
7
作者：
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