Current Status of Tissue Engineering in the Management of Severe Hypospadias.
Current Status of Tissue Engineering in the Management of Severe Hypospadias.
复制标题
组织工程在严重催化性的管理中的现状。
DOI：
10.3389/fped.2017.00283
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发表时间：
2017
影响因子：
2.6
通讯作者：
Pennisi CP
中科院分区：
文献类型：
--
作者：
Abbas TO;Mahdi E;Hasan A;AlAnsari A;Pennisi CP
以阴茎下侧尿道口错位为特征的尿道下裂是一种常见的男性出生缺陷。由于尿道下裂的解剖表现千差万别，没有一种单一的尿路成形术可以适用于所有情况。因此，出现了许多外科技术，以解决用于弥合尿路缺口所需组织的短缺，特别是在严重形式的尿道下裂。然而，目前可用的外科手术的术后并发症的比率高达四分之一的患者患有严重的尿道下裂。此外，这些尿路成形术的技术要求很高，需要相当多的手术经验。这些局限性推动了旨在简化手术程序和降低并发症发生率的新型组织工程技术的发展。几种类型的生物材料被考虑用于尿路修复，包括合成的和天然的聚合物，在某些情况下，在植入之前已经种植了细胞。这些方法已经在临床前和临床研究中进行了测试，成功程度各不相同。本文综述了不同的尿路组织工程方法，重点介绍了用于治疗尿道下裂的方法。目前，尽管取得了许多重大进展，但仍在继续寻找适用于常规临床应用的组织工程方法。
Hypospadias, characterized by misplacement of the urinary meatus in the lower side of the penis, is a frequent birth defect in male children. Because of the huge variation in the anatomic presentation of hypospadias, no single urethroplasty procedure is suitable for all situations. Hence, many surgical techniques have emerged to address the shortage of tissues required to bridge the gap in the urethra particularly in the severe forms of hypospadias. However, the rate of postoperative complications of currently available surgical procedures reaches up to one-fourth of the patients having severe hypospadias. Moreover, these urethroplasty techniques are technically demanding and require considerable surgical experience. These limitations have fueled the development of novel tissue engineering techniques that aim to simplify the surgical procedures and to reduce the rate of complications. Several types of biomaterials have been considered for urethral repair, including synthetic and natural polymers, which in some cases have been seeded with cells prior to implantation. These methods have been tested in preclinical and clinical studies, with variable degrees of success. This review describes the different urethral tissue engineering methodologies, with focus on the approaches used for the treatment of hypospadias. At present, despite many significant advances, the search for a suitable tissue engineering approach for use in routine clinical applications continues.
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影响因子：
3.7
作者：
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通讯作者：
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通讯作者：
Pellegrini, Graziella
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作者：
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通讯作者：
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