Amygdala habituation and uncinate fasciculus connectivity in adolescence: A multi-modal approach.
Amygdala habituation and uncinate fasciculus connectivity in adolescence: A multi-modal approach.
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DOI：
10.1016/j.neuroimage.2018.08.058
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发表时间：
2018-12
期刊：
影响因子：
5.7
通讯作者：
Monk CS
中科院分区：
文献类型：
--
作者：
Hein TC;Mattson WI;Dotterer HL;Mitchell C;Lopez-Duran N;Thomason ME;Peltier SJ;Welsh RC;Hyde LW;Monk CS
尽管之前对杏仁核和前额叶皮层之间的相互作用进行了广泛的研究，但很少有研究同时考虑到这一回路中的激活和结构连接，特别是当它与青少年社会情感发展有关时。目前的多模式研究描绘了钩束（UF）连接和杏仁核习惯化之间的对应关系，在一个大的青少年样本，是从人口为基础的样本。然后，我们检查了人口统计变量（年龄、性别和青春期状态）对UF连接性和杏仁核习惯化之间关系的影响。106名参与者（15-17岁）完成了DTI和fMRI情绪面孔处理任务。左UF分数各向异性与左杏仁核习惯于可怕的面孔，这表明增加结构连接的UF可能有助于杏仁核的调节。青春期状态调节了这种结构-功能关系，这种关联在那些不太成熟的人中更强。因此，UF连接可能对青春期早期的情绪调节特别重要。这项研究是第一个链接结构和功能的边缘系统电路在一个大的青少年样本与大量的少数民族参与者的代表性，提供了一个更全面的了解社会情绪发展的不足的人口。
Despite prior extensive investigations of the interactions between the amygdala and prefrontal cortex, few studies have simultaneously considered activation and structural connectivity in this circuit, particularly as it pertains to adolescent socioemotional development. The current multi-modal study delineated the correspondence between uncinate fasciculus (UF) connectivity and amygdala habituation in a large adolescent sample that was drawn from a population-based sample. We then examined the influence of demographic variables (age, gender, and pubertal status) on the relation between UF connectivity and amygdala habituation. 106 participants (15–17 years) completed DTI and an fMRI emotional face processing task. Left UF fractional anisotropy was associated with left amygdala habituation to fearful faces, suggesting that increased structural connectivity of the UF may facilitate amygdala regulation. Pubertal status moderated this structure-function relation, such that the association was stronger in those who were less mature. Therefore, UF connectivity may be particularly important for emotion regulation during early puberty. This study is the first to link structural and functional limbic circuitry in a large adolescent sample with substantial representation of ethnic minority participants, providing a more comprehensive understanding of socioemotional development in an understudied population.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
影响因子：
2.9
作者：
Hasan KM;Iftikhar A;Kamali A;Kramer LA;Ashtari M;Cirino PT;Papanicolaou AC;Fletcher JM;Ewing-Cobbs L
通讯作者：
Ewing-Cobbs L
影响因子：
4.2
作者：
Banks, Sarah J.;Eddy, Kamryn T.;Phan, K. Luan
通讯作者：
Phan, K. Luan