Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model.
Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model.
复制标题
DOI：
10.1002/jor.23333
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Soslowsky LJ
中科院分区：
文献类型：
--
作者：
Tucker JJ;Cirone JM;Morris TR;Nuss CA;Huegel J;Waldorff EI;Zhang N;Ryaby JT;Soslowsky LJ
肩袖撕裂是常见的肌肉骨骼损伤，通常需要手术干预，失败率高。目前，脉冲电磁场（PEMF）用于治疗长骨骨折和腰椎和颈椎融合手术。没有研究调查PEMF愈合软组织。因此，我们使用大鼠肩袖修复模型研究了PEMF对肩袖愈合的影响。我们假设，肩袖修复后的PEMF暴露将改善肌腱的机械性能，组织形态，并改变体内关节功能。将70只成年雄性SD大鼠分为3组：双侧PEMF修复组（n=30）、双侧PEMF修复后笼内活动组（n=30）和未损伤对照组（n=10）。手术组大鼠分别于术后4、8、16周处死。对照组于术后8周处死。随时间推移评估被动关节力学和步态分析。对左肩进行生物力学分析和µCT;对右肩进行组织学分析。结果表明，被动关节力学和关节功能无差异。在4周时，PEMF组的横截面积减少，模量和最大应力增加。在第8周，PEMF组的模量增加，中质细胞更圆。在16周时，PEMF组的骨质量有所改善。因此，结果表明，PEMF改善早期肌腱愈合，并没有改变大鼠肩袖修复模型的关节功能。肩袖修复后的PEMF暴露可改善早期肌腱愈合。
Rotator cuff tears are common musculoskeletal injuries often requiring surgical intervention with high failure rates. Currently, pulsed electromagnetic fields (PEMFs) are used for treatment of long-bone fracture and lumbar and cervical spine fusion surgery. No studies have investigated PEMF in healing soft tissue. Therefore, we investigated the effect of PEMF on rotator cuff healing using a rat rotator cuff repair model. We hypothesized that PEMF exposure following rotator cuff repair would improve tendon mechanical properties, tissue morphology, and alter in vivo joint function. 70 adult male Sprague-Dawley rats were assigned to three groups: bilateral repair with PEMF (n=30), bilateral repair followed by cage activity (n=30), uninjured control with cage activity (n=10). Rats in the surgical groups were sacrificed at 4, 8, and 16 weeks. Control group was sacrificed at 8 weeks. Passive joint mechanics and gait analysis were assessed over time. Biomechanical analysis and µCT was performed on left shoulders; histological analysis on right shoulders. Results indicate no differences in passive joint mechanics and ambulation. At 4 weeks the PEMF group had decreased cross-sectional area and increased modulus and maximum stress. At 8 weeks the PEMF group had increased modulus and more rounded cells in the midsubstance. At 16 weeks the PEMF group had improved bone quality. Therefore, results indicate that PEMF improves early tendon healing and does not alter joint function in a rat rotator cuff repair model. PEMF exposure following rotator cuff repair improves early tendon healing.
登录
查看更多内容
影响因子：
3
作者：
Beason, David P.;Connizzo, Brianne K.;Bernstein, Joseph
通讯作者：
Bernstein, Joseph
影响因子：
1.9
作者：
Strauch, Berish;Patel, Mitesh K.;Pilla, Arthur A.
通讯作者：
Pilla, Arthur A.
影响因子：
2.8
作者：
Lake, Spencer P.;Miller, Kristin S.;Elliott, Dawn M.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
2.4
作者：
Sarver, Joseph J.;Dishowitz, Michael I.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
3
作者：
Goodwin, CB;Brighton, CT;Yuan, HA
通讯作者：
Yuan, HA