Transcriptional and Epigenetic Regulation of Monocyte and Macrophage Dysfunction by Chronic Alcohol Consumption.
Transcriptional and Epigenetic Regulation of Monocyte and Macrophage Dysfunction by Chronic Alcohol Consumption.
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DOI：
10.3389/fimmu.2022.911951
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
饮酒，即使是适度的，可以影响到循环和居住的髓样细胞（粒细胞，单核细胞，巨噬细胞，树突状细胞）对循环和居住的髓样细胞的影响不成比例。 ONIC饮酒增强了炎症性介体的产生，尽管慢性饮酒与全身感染相关，但在包括脾脏，肝脏，大脑和肺部在内的多个器官中的巨噬细胞种群的研究也表明了这些细胞的功能和代谢性能受到了氧化的影响。 epigenetic landscapes. In addition, since myeloid cells are relatively short-lived in circulation and are under constant repopulation from the bone marrow compartment, alcohol’s effects on bone marrow progenitors and hematopoiesis are important for understanding the impact of alcohol systemically on these myeloid populations. Alcohol-induced disruption of progenitor, circulating, and tissue residents myeloid populations contribute to the increased susceptibility of patients with alcohol use disorders to病毒和细菌感染。 oved微生物和然而，由于表观遗传和转录景观的重新布线，单核细胞/巨噬细胞的伤口愈合反应。
Drinking alcohol, even in moderation, can affect the immune system. Studies have shown disproportionate effects of alcohol on circulating and tissue-resident myeloid cells (granulocytes, monocytes, macrophages, dendritic cells). These cells orchestrate the body’s first line of defense against microbial challenges as well as maintain tissue homeostasis and repair. Alcohol’s effects on these cells are dependent on exposure pattern, with acute drinking dampening but chronic drinking enhancing production of inflammatory mediators. Although chronic drinking is associated with heightened systemic inflammation, studies on tissue resident macrophage populations in several organs including the spleen, liver, brain, and lung have also shown compromised functional and metabolic capacities of these cells. Many of these effects are thought to be mediated by oxidative stress caused by alcohol and its metabolites which can directly impact the cellular epigenetic landscapes. In addition, since myeloid cells are relatively short-lived in circulation and are under constant repopulation from the bone marrow compartment, alcohol’s effects on bone marrow progenitors and hematopoiesis are important for understanding the impact of alcohol systemically on these myeloid populations. Alcohol-induced disruption of progenitor, circulating, and tissue resident myeloid populations contribute to the increased susceptibility of patients with alcohol use disorders to viral and bacterial infections. In this review, we provide an overview of the impact of chronic alcohol consumption on the function of monocytes and macrophages in host defense, tissue repair and inflammation. We then summarize our current understanding of the mechanisms underlying alcohol-induced disruption and examine changes in transcriptome and epigenome of monocytes and mcrophages. Overall, chronic alcohol consumption leads to hyper-inflammation concomitant with decreased microbial and wound healing responses by monocytes/macrophages due to a rewiring of the epigentic and transcriptional landscape. However, in advanced alcoholic liver disease, myeloid cells become immunosuppressed as a response to the surrounding hyper-inflammatory milieu. Therefore, the effect of chronic alcohol on the inflammatory response depends on disease state and the immune cell population.
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影响因子：
1
作者：
Amedee, Angela M.;Nichols, Whitney A.;Nelson, Steve
通讯作者：
Nelson, Steve
影响因子：
4.8
作者：
Bala, Shashi;Marcos, Miguel;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
1.5
作者：
Baum, Marianna K.;Rafie, Carlin;Campa, Adriana
通讯作者：
Campa, Adriana
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM
猴子中的慢性酒精自我给药显示长期数量/频率分类稳定性。
DOI：
10.1111/acer.12547
发表时间：
2014-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Baker EJ;Farro J;Gonzales S;Helms C;Grant KA
通讯作者：
Grant KA