Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.
Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.
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DOI：
10.3389/fnhum.2022.1016064
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
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经椎磁刺激（TVMS）的人腰髓可以引起双侧节律性腿部运动，如在步行中，推测通过激活脊髓运动神经回路。然而，一个适当的刺激强度，可以有效地驱动人类脊髓运动电路，唤起步行样运动尚未确定。为了解决这个问题，在健康成人中以不同的刺激强度（最大刺激器输出的10-70%）在腰髓（L1-L3）的椎间隙上输送TVMS。以刺激强度依赖的方式，TVMS诱发了两种主要模式的节奏腿运动，其中左右运动周期与不同的相位关系相协调：跳跃样运动，其中双腿在相同的方向上移动的相位，和步行样运动，其中双腿交替移动的反相;未分类的运动也被观察到，不能被归类为任何运动类型。即使在同一刺激部位，随着刺激强度的增加，刺激诱发的节律性运动也从跳跃样运动转变为行走样运动。不同的腿部肌肉激活模式参与了跳跃和步行样运动的诱导。诱发的跳跃和步行样运动的幅度与刺激强度呈正相关。人类脊髓神经回路需要更高强度的磁刺激来产生类似行走的腿部运动，而不是产生类似跳跃的运动。这些结果表明，TVMS激活了人类脊髓中不同的神经模块，以产生跳跃和步行样运动。
Transvertebral magnetic stimulation (TVMS) of the human lumbar spinal cord can evoke bilateral rhythmic leg movements, as in walking, supposedly through the activation of spinal locomotor neural circuitry. However, an appropriate stimulus intensity that can effectively drive the human spinal locomotor circuitry to evoke walking-like movements has not been determined. To address this issue, TVMS was delivered over an intervertebral space of the lumbar cord (L1–L3) at different stimulus intensities (10–70% of maximum stimulator output) in healthy human adults. In a stimulus intensity-dependent manner, TVMS evoked two major patterns of rhythmic leg movements in which the left-right movement cycles were coordinated with different phase relationships: hopping-like movements, in which both legs moved in the same direction in phase, and walking-like movements, in which both legs moved alternatively in anti-phase; uncategorized movements were also observed which could not be categorized as either movement type. Even at the same stimulation site, the stimulus-evoked rhythmic movements changed from hopping-like movements to walking-like movements as stimulus intensity was increased. Different leg muscle activation patterns were engaged in the induction of the hopping- and walking-like movements. The magnitude of the evoked hopping- and walking-like movements was positively correlated with stimulus intensity. The human spinal neural circuitry required a higher intensity of magnetic stimulation to produce walking-like leg movements than to produce hopping-like movements. These results suggest that TVMS activates distinct neural modules in the human spinal cord to generate hopping- and walking-like movements.
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影响因子：
--
作者：
Kiehn, Ole;Quinlan, Katharina A.;Endo, Toshiaki
通讯作者：
Endo, Toshiaki
DOI：
10.1038/nrn.2016.9
发表时间：
2016-04
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Kiehn O
通讯作者：
Kiehn O
影响因子：
16.6
作者：
Pocratsky AM;Burke DA;Morehouse JR;Beare JE;Riegler AS;Tsoulfas P;States GJR;Whittemore SR;Magnuson DSK
通讯作者：
Magnuson DSK
DOI：
10.1111/j.1749-6632.1998.tb09062.x
发表时间：
1998-01-01
期刊：
NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY
影响因子：
--
作者：
Dimitrijevic, MR;Gerasimenko, Y;Pinter, MM
通讯作者：
Pinter, MM
影响因子：
2.5
作者：
Kato, Kenji;Sasada, Syusaku;Nishimura, Yukio
通讯作者：
Nishimura, Yukio