Prefrontal-limbic Functional Connectivity during Acquisition and Extinction of Conditioned Fear.
Prefrontal-limbic Functional Connectivity during Acquisition and Extinction of Conditioned Fear.
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DOI：
10.1016/j.neuroscience.2018.02.022
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发表时间：
2018-04-15
期刊：
影响因子：
3.3
通讯作者：
Gonzalez-Lima F
中科院分区：
文献类型：
--
作者：
Barrett DW;Gonzalez-Lima F
本研究为获得巴甫洛夫恐惧习得和音足冲击消退过程中前额叶-边缘区功能连通性的新代谢数据提供了新的分析方法。用氟脱氧葡萄糖（FDG）放射自显影法对小鼠进行脑区域活动代谢图分析。新的FDG数据来自缰核和其他涉及厌恶条件反射的区域，如边缘下皮层、杏仁核和导水管周围灰质区。在习得、消失或伪随机训练过程中，这些区域的活动模式相互关联，形成功能连接模型。habenular复合体的两个分支在获得相对于消失后显示出增加的活性，而伪随机组介于其他两组之间。在杏仁核中央内侧、背内侧和腹外侧的导水管周围灰质中也发现了显著的获得性激活效应。在消失过程中，FDG摄取增加仅发生在背侧和腹侧边缘下皮层。这些区域之间的整体活动相关性模式显示，在获取和消失训练期间，这些区域的功能连通性广泛但不同，而在伪随机训练后，功能连通性较少。有趣的是，在灭绝过程中，缰核与杏仁核表现出明显的相互关联模式。功能连接模型揭示了在巴甫洛夫恐惧习得和消退过程中，边缘下皮层、杏仁核、缰核和导水管周围灰色区之间相互作用的变化。本研究提供了关于缰核对恐惧条件反射的贡献的新数据，并揭示了以前未报道的缰核下-杏仁核-缰核-导水管周围灰色相互作用与条件恐惧的获得和消除有关。
This study is a new analysis to obtain novel metabolic data on the functional connectivity of prefrontal-limbic regions in Pavlovian fear acquisition and extinction of tone-footshock conditioning. Mice were analyzed with the fluorodeoxyglucose (FDG) autoradiographic method to metabolically map regional brain activity. New FDG data were sampled from the nuclei of the habenula and other regions implicated in aversive conditioning, such as infralimbic cortex, amygdala and periaqueductal gray regions. The activity patterns among these regions were inter-correlated during acquisition, extinction or pseudorandom training to develop a functional connectivity model. Two subdivisions of the habenular complex showed increased activity after acquisition relative to extinction, with the pseudorandom group intermediate between the other two groups. Significant acquisition activation effects were also found in centromedial amygdala, dorsomedial and ventrolateral periaqueductal gray. FDG uptake increases during extinction were found only in dorsal and ventral infralimbic cortex. The overall pattern of activity correlations between these regions revealed extensive but differential functional connectivity during acquisition and extinction training, with less functional connectivity found after pseudorandom training. Interestingly, habenula nuclei showed a distinct pattern of inter-correlations with amygdala nuclei during extinction. The functional connectivity model revealed changing interactions among infralimbic cortex, amygdala, habenula and periaqueductal gray regions through the stages of Pavlovian fear acquisition and extinction. This study provided new data on the contributions of the habenula to fear conditioning, and revealed previously unreported infralimbic-amygdala-habenula-periaqueductal gray interactions implicated in acquisition and extinction of conditioned fear.
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