Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss.
Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss.
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DOI：
10.2337/db13-1546
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发表时间：
2014-06
期刊：
影响因子：
7.7
通讯作者：
Van Cauter E
中科院分区：
文献类型：
--
作者：
Leproult R;Holmbäck U;Van Cauter E
轮班工人的睡眠时间不规律，导致睡眠剥夺和昼夜节律失调，与白班工人相比，他们患糖尿病的风险更高。在健康成人中，没有昼夜节律失调的睡眠限制会促进胰岛素抵抗。为了确定轮班工作中通常发生的昼夜节律失调是否涉及独立于睡眠不足的内在不良代谢影响，研究人员采用平行组设计对26名健康成年人进行了研究。两种干预措施都包括住院3天，睡眠时间为10小时，随后住院8天，睡眠限制为5小时，夜间就寝时间固定（昼夜节律一致），或8天中的4天就寝时间延迟8.5小时（昼夜节律不一致）。在对齐和不对齐条件下，干预期间的每日总睡眠时间（SD）几乎相同（4小时48分钟[5分钟]vs. 4小时45分钟[6分钟]）。在两组中，睡眠限制后胰岛素敏感性（SI）显著降低，胰岛素分泌没有代偿性增加，炎症增加。在暴露于昼夜节律失调的男性参与者中，SI的减少和炎症的增加都是那些保持正常夜间就寝时间的人的两倍。轮班工作中发生的昼夜节律失调可能会增加糖尿病和炎症的风险，而这与睡眠不足无关。
Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss.
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影响因子：
5.4
作者：
Boston, Ray C;Stefanovski, Darko;Bergman, Richard N
通讯作者：
Bergman, Richard N
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
DOI：
10.1073/pnas.1010666108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Duffy, Jeanne F.;Cain, Sean W.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
8.9
作者：
Gallant, A. R.;Lundgren, J.;Drapeau, V.
通讯作者：
Drapeau, V.
影响因子：
4.4
作者：
Ansar, Waliza;Ghosh, Shyamasree
通讯作者：
Ghosh, Shyamasree