The value of AIDS incidence data in assessing the spread of HIV infection.

The value of AIDS incidence data in assessing the spread of HIV infection.
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艾滋病发病率数据在评估艾滋病毒感染传播方面的价值。

DOI:
10.1002/sim.4780080106
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发表时间:
1989
影响因子:
2
通讯作者:
Lagakos,SW
Lagakos,SW
中科院分区:
医学3区
文献类型:
--
作者:
DeGruttola,V;Lagakos,SW

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艾滋病累计病例数随时间的变化复杂地取决于这一流行病的若干特征,包括感染人体免疫机能丧失病毒(艾滋病毒)和出现艾滋病症状之间的诱导时间分布、性行为、伴侣选择和静脉注射毒品等行为的异质性以及这些行为随时间的变化。因此,自1982年首次认识到艾滋病以来,所观察到的艾滋病累积发病率从5个月增加到13个月的时间增加了一倍,这既不表明这一流行病已经开始“自然发展”,也不表明行为变化对降低发病率产生了重大影响。即使在已知诱导分布的同质人口中,艾滋病发病率数据目前在确定感染艾滋病毒的人数方面价值不大,除非有关于艾滋病毒感染累积发病率曲线形状的额外信息。
Changes over time in the cumulative number of cases of AIDS depend in a complex way on several features of the epidemic, including the distribution of the induction time between infection with the human immunodeficiency virus (HIV) and onset of symptoms of AIDS, heterogeneity in such behaviours as sexual practices, selection of partners, and IV drug use, and changes over time in these behaviours. Consequently, the observed increase in the doubling time in cumulative AIDS incidence from 5 to 13 months, since AIDS was first recognized in 1982, demonstrates neither that the epidemic has begun to ‘run its course’ nor that behavioural changes have had a major impact in reducing incidence. Even in a homogeneous population with known induction distribution, AIDS incidence data currently are of little value in determining the number of persons infected with HIV unless additional information is available about the shape of cumulative incidence curve of HIV infection.
HIV 感染和静脉吸毒:传播动态、感染结果和预防的关键问题。
DOI: 10.1093/clinids/10.1.151
发表时间: 1988
期刊: Reviews of infectious diseases
影响因子: --
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