A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster.
A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster.
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DOI：
10.1016/j.cub.2010.04.009
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发表时间：
2010-06-08
期刊：
影响因子：
9.2
通讯作者：
Kapahi, Pankaj
中科院分区：
文献类型：
--
作者：
Vargas, Misha A.;Luo, Ningguang;Yamaguchi, Atsushi;Kapahi, Pankaj
平衡各种营养物质的摄入对生物体的生长、繁殖和生存至关重要。在发育或环境变化后，由于营养需求的变化，生物体的最佳饮食发生了变化，这被称为饮食转换，已经在几个物种中观察到。我们证明雌性黑腹d.m anogaster在交配后也经历了饮食转换，导致对酵母的偏好增加，酵母是它们饮食中蛋白质的主要来源。我们证明了S6激酶（S6K）和血清素的产生与交配后的饮食转换有关。为了进一步研究黑腹扁蝇平衡营养摄入的能力，我们研究了在饮食中剥夺酵母或蔗糖后成虫的饮食偏好。我们观察到，在缺乏碳水化合物或酵母的饮食条件下，当允许自由选择饮食时，黑腹d对缺乏营养的食物表现出强烈的偏好。此外，激活S6K或喂食5 -羟色胺前体的果蝇在本实验中表现出对酵母的偏好增强。我们的研究结果表明，TOR信号和血清素可能在维持黑腹龙的营养平衡中发挥重要作用。因此，黑腹巨藻可以作为研究营养稳态遗传基础的模式生物，有助于我们对肥胖和糖尿病等代谢性疾病的理解。
Balancing intake of diverse nutrients is important for organismal growth, reproduction and survival. A shift in an organism’s optimal diet due to changes in nutritional requirements after developmental or environmental changes is referred to as dietary switch, and has been observed in several species. We demonstrate that female D. melanogaster also undergo a dietary switch following mating that leads to an increased preference for yeast, the major source of protein in their diet. We demonstrate that S6 Kinase (S6K) and serotonin production are involved in the post-mating dietary switch. To further investigate the ability of D. melanogaster to balance nutrient intake, we examined the dietary preferences of adult flies following deprivation of yeast or sucrose in the diet. We observe that following conditioning on a diet deficient in either carbohydrates or yeast, D. melanogaster shows a strong preference for the deficient nutrient when permitted to choose its diet freely. Furthermore, flies with activated S6K or fed a serotonin precursor exhibit enhanced preference for yeast in this assay. Our results suggest that TOR signaling and serotonin may play an important role in maintaining nutrient balance in D. melanogaster. Hence, D. melanogaster can be used as a model organism to investigate the genetic basis for nutrient homeostasis which may contribute to our understanding of metabolic disorders such as obesity and diabetes.
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影响因子：
2.1
作者：
Chippindale, AK;Leroi, AM;Rose, MR
通讯作者：
Rose, MR
影响因子：
9.2
作者：
Carvalho, GB;Kapahi, P;Benzer, S
通讯作者：
Benzer, S
DOI：
10.1073/pnas.0501914102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Wu, Q;Zhang, Y;Shen, P
通讯作者：
Shen, P
影响因子：
7.8
作者：
Skorupa, Danielle A.;Dervisefendic, Azra;Pletcher, Scott D.
通讯作者：
Pletcher, Scott D.
影响因子：
8.9
作者：
Simpson, SJ;Raubenheimer, D
通讯作者：
Raubenheimer, D