In young women, a link between childhood abuse and subliminal processing of aversive cues is moderated by impulsivity.
In young women, a link between childhood abuse and subliminal processing of aversive cues is moderated by impulsivity.
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在年轻女性中，童年虐待与厌恶线索的潜意识处理之间的联系被冲动性所缓和。
DOI：
10.1186/s12888-022-03770-0
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发表时间：
2022-03-02
期刊：
影响因子：
4.4
通讯作者：
Childress AR
中科院分区：
文献类型：
--
作者：
Regier PS;Sinko L;Jagannathan K;Aryal S;Teitelman AM;Childress AR
虐待儿童是一个严重的公共卫生问题。儿童虐待、不良行为、心理健康结果和大脑功能和结构改变之间的关联已经开始被描述。关于虐待亚型与唤起线索的线索反应的具体关联以及混杂的心理健康/行为变量的调节作用知之甚少。54个新兴的成年女性（18-24岁）完成了行为，心理健康和儿童虐待的评估。他们参与了一项功能磁共振成像任务，该任务的特点是被动观看由“向后掩蔽”提供的唤起（33毫秒）线索，以防止有意识的处理。评估了虐待/忽视评分、行为/心理健康因素和脑功能的相关性。后续分析调查了行为/心理健康因素对虐待和大脑关系的调节作用。儿童期虐待和忽视的频率越高，冲动性、抑郁症状和焦虑依恋的得分越高。儿童期虐待与内侧眶额皮质（mOFC）对厌恶（与中性）线索的反应增加呈正相关。在行为/心理健康变量中，只有冲动性似乎对儿童期虐待和大脑对厌恶性线索的反应之间的关系有调节作用。儿童期虐待和mOFC对“看不见的”厌恶刺激的反应增强之间的联系，由冲动调节，增加了关于先前逆境对大脑功能影响的越来越多的文献。这些发现为儿童期虐待影响大脑处理负面刺激的方式提供了进一步的理解，有助于解释儿童期虐待与成年后各种不良后果之间的联系。在线版本包含补充材料，可通过10.1186/s12888-022-03770-0获得。
Childhood maltreatment is a serious public health concern. The association between child maltreatment, adverse behaviors, mental health outcomes, and alterations to brain function and structure have begun to be characterized. Less is known about the specific associations of maltreatment subtypes with cue-response to evocative cues and the moderating effects of confounding mental health/behavioral variables. Fifty-four emerging adult women (aged 18–24) completed assessments for behaviors, mental health, and childhood maltreatment. They participated in a fMRI task featuring passive viewing of evocative (33 ms) cues presented by “backward masking” to prevent conscious processing. Correlations of abuse/neglect scores, behavioral/mental health factors, and brain function were assessed. Follow-up analyses investigated the moderating effects of behavioral/mental health factors on maltreatment and brain relationships. Greater frequency of childhood abuse and neglect were correlated with higher scores of impulsivity, depressive symptoms, and anxious attachment. Childhood abuse was positively associated with increased medial orbitofrontal cortical (mOFC) response to aversive (vs. neutral) cues. Among the behavioral/mental health variables, only impulsivity appeared to have a moderating effect on the relationship between childhood abuse and brain response to aversive cues. The link between childhood abuse and a heightened mOFC response to “unseen” aversive stimuli, moderated by impulsivity, adds to the growing literature on the impact of prior adversity on brain function. These findings offer further understanding for the way in which childhood maltreatment affects the brain processing of negative stimuli, helping to explain the well-documented link between childhood maltreatment and a variety of adverse outcomes in adulthood. The online version contains supplementary material available at 10.1186/s12888-022-03770-0.
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