The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm.
The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm.
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DOI：
10.1016/j.jpeds.2017.02.064
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Extremely Low Gestational Age Newborns Study Investigators
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文献类型：
--
作者：
Jensen ET;van der Burg JW;O'Shea TM;Joseph RM;Allred EN;Heeren T;Leviton A;Kuban KCK;Extremely Low Gestational Age Newborns Study Investigators
To assess the association between maternal pre-pregnancy BMI and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm. Study participants were 535 ten-year-old children previously enrolled in the prospective multicenter Extremely Low Gestational Age Newborns (ELGAN) cohort study, who were products of singleton pregnancies. Soon after delivery mothers provided information about pre-pregnancy weight. Pre-pregnancy BMI and adequacy of weight gain were characterized based on this information. Children underwent a neurocognitive evaluation at 10 years of age. Maternal pre-pregnancy obesity was associated with increased odds of a lower score for Differential Ability Scales-II Verbal IQ, for Developmental Neuropsychological Assessment-II measures of processing speed and visual fine motor control, and for Wechsler Individual Achievement Test-III (WIAT-III) Spelling. Children born to mothers who gained an excessive amount of weight were at increased odds of a low score on the Oral and Written Language Scales (OWLS) Oral Expression assessment. Conversely, children whose mother did not gain an adequate amount of weight were at increased odds of a lower score on the OWLS Oral Expression and WIAT-III Word Reading assessments. In this cohort of extremely preterm infants, maternal obesity was associated with poorer performance on some assessments of neurocognitive function. Our findings are consistent with the observational and experimental literature and suggest that opportunities may exist to mitigate risk through education and behavioral intervention before pregnancy.
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