Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice.
Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice.
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DOI：
10.1038/s41598-020-73988-z
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发表时间：
2020-10-09
影响因子：
4.6
通讯作者：
Yamada M
中科院分区：
文献类型：
--
作者：
Nakatake Y;Furuie H;Ukezono M;Yamada M;Yoshizawa K;Yamada M
啮齿类动物用视觉感知同种物质的情绪状态。在本研究中，我们证明了暴露于同种异物的录像痛苦中会诱导雄性C57BL/6J小鼠的应激反应。单次暴露在视频记录的社会失败应激(SDS)场景中，这些小鼠的血浆皮质酮水平增加。这一生理变化被视觉信息阻断而被抑制，这表明视觉在诱导应激反应中起着关键作用。此外，在接触视频后，在前扣带回皮质和其他与负价和共情系统相关的脑区，c-Fos阳性神经元的数量增加，但与疼痛信号相关的区域没有。此外，反复接触SDS视频导致蔗糖偏好测试中的奖励敏感度明显降低，但不影响社交测试中的回避行为或强迫游泳测试中的不动行为。老鼠对奖励的敏感度降低反映出快感缺乏，这是人类抑郁症的核心症状。因此，我们的视频SDS模型提供了一个独特的机会，不仅可以了解应激诱导的快感缺乏症的潜在机制，而且还可以以更高的重复性筛选与应激相关的障碍的有效候选分子。
Rodents perceive the emotional states of conspecifics using vision. In the present study, we demonstrated that exposure to the video-recorded distress of conspecifics induces stress responses in male C57BL/6J mice. A single exposure to a video-recorded scene of the social defeat stress (SDS) increased plasma corticosterone levels in these mice. This physiological change was suppressed by blocking the visual information, suggesting that vision plays a crucial role in inducing stress responses. Furthermore, after exposure to the video, there were increased numbers of c-Fos-positive neurons in the anterior cingulate cortex and other brain areas that are associated with the negative valence and empathy systems, but not in the regions related to the pain signaling. In addition, repeated exposure to SDS videos induced an apparent reduction in reward sensitivity in the sucrose preference test, but did not affect avoidance behaviour in the social interaction test or immobility behaviour in the forced swim test. Reduced reward sensitivity in mice reflects anhedonia, which is a core symptom of depression in humans. Our video SDS model therefore provides a unique opportunity to not only understand the mechanisms underlying stress-induced anhedonia, but also to screen effective candidate molecules for stress-related disorders with greater reproducibility.
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影响因子：
16.6
作者：
Sakaguchi T;Iwasaki S;Okada M;Okamoto K;Ikegaya Y
通讯作者：
Ikegaya Y
DOI：
10.1073/pnas.1316265110
发表时间：
2014-01-07
影响因子：
11.1
作者：
Holman, E. Alison;Garfin, Dana Rose;Silver, Roxane Cohen
通讯作者：
Silver, Roxane Cohen
影响因子：
4.1
作者：
Blanchard, EB;Kuhn, E;Steckler, DC
通讯作者：
Steckler, DC
影响因子：
5
作者：
PORSOLT, RD;BERTIN, A;JALFRE, M
通讯作者：
JALFRE, M
移情是由小鼠的遗传背景调节的。
影响因子：
3.7
作者：
Chen Q;Panksepp JB;Lahvis GP
通讯作者：
Lahvis GP