Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.
Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.
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乳清蛋白对能量平衡的影响将肠道能量吸收机制与肥胖和下丘脑神经肽基因表达联系起来。
DOI：
10.1152/ajpendo.00356.2016
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Nilaweera KN
中科院分区：
文献类型：
--
作者：
Nilaweera KN
我们测试了一种假设，即饮食中的乳清蛋白分离蛋白(WPI)影响与能量吸收相关的肠道机制，并通过改变能量平衡来弥补由此产生的能量不足，以支持生长。给C57BL/6小鼠饲喂不同蔗糖含量的WPI，研究其对能量平衡相关参数的影响。作为高蔗糖饮食的一部分，WPI降低了下丘脑阿片黑素皮质素原基因的表达，并增加了能量摄入。能量消耗未受影响，但附睾体质量减轻，表明能量损失。值得注意的是，回肠氨基酸转运蛋白SLC6a19、葡萄糖转运蛋白2和脂肪酸转运蛋白4的基因表达减少。肠道微生物区系的组成也发生了变化，肠道微生物减少。上述变化表明通过肠道的能量吸收减少。我们认为，这调动了脂肪组织中的能量，并引起下丘脑的变化，增加了能量的摄取，从而抵消了肠道中产生的能量不足。降低WPI日粮中的蔗糖含量会增加能量消耗。这进一步降低了附睾重量和血浆瘦素，从而使下丘脑Ghrelin基因表达和肠道重量均增加。这些数据表明，当肠道-脂肪-下丘脑途径受到额外的能量损失(现在在脂肪组织中)时，代偿性变化试图吸收更多的能量。值得注意的是，WPI和蔗糖含量相互作用，使这一途径的组成部分机制成为可能。
We tested the hypothesis that dietary whey protein isolate (WPI) affects the intestinal mechanisms related to energy absorption and that the resulting energy deficit is compensated by changes in energy balance to support growth. C57BL/6 mice were provided a diet enriched with WPI with varied sucrose content, and the impact on energy balance-related parameters was investigated. As part of a high-sucrose diet, WPI reduced the hypothalamic expression of pro-opiomelanocortin gene expression and increased energy intake. The energy expenditure was unaffected, but epididymal weight was reduced, indicating an energy loss. Notably, there was a reduction in the ileum gene expression for amino acid transporter SLC6a19, glucose transporter 2, and fatty acid transporter 4. The composition of the gut microbiota also changed, whereFirmicuteswere reduced. The above changes indicated reduced energy absorption through the intestine. We propose that this mobilized energy in the adipose tissue and caused hypothalamic changes that increased energy intake, acting to counteract the energy deficit arising in the intestine. Lowering the sucrose content in the WPI diet increased energy expenditure. This further reduced epididymal weight and plasma leptin, whereupon hypothalamic ghrelin gene expression and the intestinal weight were both increased. These data suggest that when the intestine-adipose-hypothalamic pathway is subjected to an additional energy loss (now in the adipose tissue), compensatory changes attempt to assimilate more energy. Notably, WPI and sucrose content interact to enable the component mechanisms of this pathway.
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DOI：
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