Vaporized Hydrogen Peroxide Decontamination of N95 Respirators in a Dedicated Animal Research Facility for Reuse During a Novel Coronavirus Pandemic
Vaporized Hydrogen Peroxide Decontamination of N95 Respirators in a Dedicated Animal Research Facility for Reuse During a Novel Coronavirus Pandemic
复制标题
DOI：
10.1177/1535676020936381
复制
发表时间：
2020-09-01
期刊：
影响因子：
--
通讯作者：
Griffis S
中科院分区：
文献类型：
--
作者：
Hankenson FC;Mauntel M;Willard J;Pittsley L;Degg W;Burnell N;Vierling A;Griffis S
在COVID-19大流行期间，医疗保健系统和安全提供者面临前所未有的挑战，因为无法获得有限的个人防护设备（PPE）来进行患者和公共护理。在联邦紧急情况下，消毒后的PPE可以通过疾病控制和预防中心推荐的汽化过氧化氢（VHP）等工艺重复使用。我们在我们的机构确定了一个空置的动物饲养设施，将其重新用于区域VHP净化中心。该设施是一个多房间，20 000平方英尺的建筑物，具有HVAC控制，以适应VHP条件要求。使用机器人HaloFoggers将H2 O2输送到房间，分散H2 O2蒸汽和越来越浓缩的微滴作为雾，持续基于房间立方英尺的时间段。雾化循环在循环后7天内消除了6-log嗜热脂肪土芽孢杆菌。经治疗的N95的功能有效性通过机构人员的适合性测试来证实。标牌、工艺流程图和培训材料有助于简化工作流程并遵守建筑物内的安全预期。我们的研究确定，在受控的雾/停留/排气循环中，使用VHP能够清除各种N95呼吸器类型和尺寸的潜在细菌和病毒因子。这座改造后的动物设施每天有能力净化多达6700个呼吸器，这将解决该州预计的COVID-19病例激增问题，并最终允许每个呼吸器多次重复使用。该地区没有其他公共场所有我们的能力来抵消持续的PPE需求供应链问题。
During the COVID-19 pandemic, health care systems and safety providers have faced an unprecedented challenge of limited access to personal protective equipment (PPE) to conduct patient and public care. In federal emergencies, reuse of PPE after disinfection can occur by processes, like vaporized hydrogen peroxide (VHP), recommended by the Centers for Disease and Control and Prevention. We identified a vacant animal holding facility at our institution to repurpose into a regional VHP decontamination center. The facility is a multiroom, 20 000 ft2 building with control of HVAC to adjust to VHP conditional requirements. H2O2 was delivered to rooms using robotic HaloFoggers, dispersing H2O2 vapor and increasingly concentrated microdroplets as a fog for a timed period based on cubic footage of rooms. Fogging cycles eliminated 6-log Geobacillus stearothermophilus up to 7 days postcycle. Functional efficacy of treated N95s was confirmed by fit tests of institutional personnel. Signage, process flow mapping, and training materials facilitated ease of workflow and adherence to safety expectations within the building. Our study determined that a variety of N95 respirator types and sizes were able to be cleared of potential bacterial and viral agents using VHP in a controlled fog/dwell/exhaust cycle. This repurposed animal facility has the capacity to decontaminate up to 6700 respirators daily, which will address the predicted surge of COVID-19 cases in the state, and ultimately allow each respirator to be reused multiple times. There is no other public site in the region with our capacity to offset the continued supply chain issues for PPE needs.
登录
查看更多内容
DOI：
10.1016/j.jhin.2014.02.003
发表时间：
2014-04
期刊：
The Journal of hospital infection
影响因子：
--
作者：
Goyal SM;Chander Y;Yezli S;Otter JA
通讯作者：
Otter JA
影响因子：
4
作者：
Rogers, JV;Sabourin, CLK;Chang, J
通讯作者：
Chang, J
影响因子：
6.9
作者：
Davies, A.;Pottage, T.;Walker, J.
通讯作者：
Walker, J.
DOI：
10.30802/aalas-jaalas-17-000135
发表时间：
2018-09-01
影响因子：
1.7
作者：
Miedel, Emily L.;Ragland, Natalie H.;Engelman, Robert W.
通讯作者：
Engelman, Robert W.
影响因子：
6.9
作者：
Bentley, K.;Dove, B. K.;Bennett, A. M.
通讯作者：
Bennett, A. M.