Silkworm Sericin: Properties and Biomedical Applications.
Silkworm Sericin: Properties and Biomedical Applications.
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DOI：
10.1155/2016/8175701
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发表时间：
2016
影响因子：
--
通讯作者：
Natali MR
中科院分区：
文献类型：
--
作者：
Kunz RI;Brancalhão RM;Ribeiro LF;Natali MR
丝胶是由家蚕（Bombyx mori）产生的天然聚合物，它包围并保持茧中丝线中的两根丝素细丝。回收和再利用纺织工业通常废弃的丝胶不仅可以最大限度地减少环境问题，而且具有很高的科学和商业价值。该分子的理化性质决定了其在生物医学中的众多应用，并受到提取方法和蚕谱系的影响，这可能导致丝胶的分子量和氨基酸浓度发生变化。高疏水性氨基酸的存在及其抗氧化潜力使得丝胶在食品和化妆品工业中的应用成为可能。其保湿能力可作为伤口愈合、刺激细胞增殖、防止紫外线辐射以及配制面霜和洗发水的治疗剂。丝胶的抗氧化活性与低消化率相关，扩大了其在医学领域的应用，例如抗肿瘤、抗菌和抗炎剂、抗凝血剂，有助于结肠健康，改善便秘，并通过改善血浆脂质分布来保护身体免受肥胖的影响。此外，丝胶的特性允许其在组织工程和药物输送中用作培养基和冷冻保存，证明了其作为重要生物材料的有效用途。
Silk sericin is a natural polymer produced by silkworm, Bombyx mori, which surrounds and keeps together two fibroin filaments in silk thread used in the cocoon. The recovery and reuse of sericin usually discarded by the textile industry not only minimizes environmental issues but also has a high scientific and commercial value. The physicochemical properties of the molecule are responsible for numerous applications in biomedicine and are influenced by the extraction method and silkworm lineage, which can lead to variations in molecular weight and amino acid concentration of sericin. The presence of highly hydrophobic amino acids and its antioxidant potential make it possible for sericin to be applied in the food and cosmetic industry. The moisturizing power allows indications as a therapeutic agent for wound healing, stimulating cell proliferation, protection against ultraviolet radiation, and formulating creams and shampoos. The antioxidant activity associated with low digestibility of sericin that expands the application in the medical field, such as antitumour, antimicrobial and anti-inflammatory agent, anticoagulant, acts in colon health, improving constipation and protects the body from obesity through improved plasma lipid profile. In addition, the properties of sericin allow its application as a culture medium and cryopreservation, in tissue engineering and for drug delivery, demonstrating its effective use, as an important biomaterial.
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影响因子：
6.1
作者：
Chen Z;Yang S;He Y;Song C;Liu Y
通讯作者：
Liu Y
DOI：
10.1152/ajpregu.00049.2014
发表时间：
2014-07-01
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
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影响因子：
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作者：
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通讯作者：
Carlos da Silva, Meuris Gurgel
影响因子：
2.8
作者：
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通讯作者：
Yamdech, Rungnapha
影响因子：
2.8
作者：
Aramwit, Pornanong;Damrongsakkul, Siriporn;Srichana, Teerapol
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Srichana, Teerapol