Long Non-coding RNAs: Mechanisms, Experimental, and Computational Approaches in Identification, Characterization, and Their Biomarker Potential in Cancer.
Long Non-coding RNAs: Mechanisms, Experimental, and Computational Approaches in Identification, Characterization, and Their Biomarker Potential in Cancer.
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长链非编码rna：鉴定、表征及其在癌症中的生物标志物潜力的机制、实验和计算方法。
DOI：
10.3389/fgene.2021.649619
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发表时间：
2021
影响因子：
3.7
通讯作者：
Schneider R
中科院分区：
文献类型：
--
作者：
Chowdhary A;Satagopam V;Schneider R
长非编码RNA是长度>200个碱基对的多种非编码RNA分子，具有多种功能，如基因调控、剂量补偿、表观遗传调控。几种lncRNA的失调和基因组变异与几种疾病有关。它们的组织和发育特异性表达是它们成为细胞生理状态的可行指标的贡献因素。本文综述了lncRNA的分子机制和功能、最新的实验和计算流程以及lncRNA的鉴定和功能注释所面临的挑战，并展望了其作为生物标志物的前景。我们还说明了共表达网络在TCGA-LIHC数据集上的应用，用于对在肝细胞癌（HCC）中具有治疗潜力的lncRNA进行推定的功能预测。
Long non-coding RNAs are diverse class of non-coding RNA molecules >200 base pairs of length having various functions like gene regulation, dosage compensation, epigenetic regulation. Dysregulation and genomic variations of several lncRNAs have been implicated in several diseases. Their tissue and developmental specific expression are contributing factors for them to be viable indicators of physiological states of the cells. Here we present an comprehensive review the molecular mechanisms and functions, state of the art experimental and computational pipelines and challenges involved in the identification and functional annotation of lncRNAs and their prospects as biomarkers. We also illustrate the application of co-expression networks on the TCGA-LIHC dataset for putative functional predictions of lncRNAs having a therapeutic potential in Hepatocellular carcinoma (HCC).
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影响因子：
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作者：
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DOI：
10.1093/database/bat034
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作者：
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