Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism.
Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism.
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DOI：
10.1016/j.celrep.2023.112662
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发表时间：
2023-06-27
期刊：
影响因子：
8.8
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中科院分区：
文献类型：
--
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突触可塑性被假设为海马尖波/涟漪（SWR）为基础的合奏活动，以促进系统水平的记忆巩固协调的SWR和皮层睡眠纺锤波的突出经验的基础“重放”。目前尚不清楚突触的分子变化如何有助于经验诱导的网络功能修改。突触蛋白KIBRA调节可塑性和记忆。为了确定KIBRA调节的可塑性对回路动力学的影响，我们记录了野生型（WT）小鼠和缺乏KIBRA的同窝小鼠的体内神经活动，并在新体验之前、期间和之后检查了回路功能。在WT小鼠中，经历改变的群体活动和振荡动力学，其方式与在重放中并入新的信息内容和增强的皮层-皮层通信一致。虽然KIBRA条件性敲除（cKO）小鼠的基线SWR特征正常，但不存在SWR的经验依赖性改变。此外，海马内和海马皮质通信在SWR中断KIBRA删除后。这些结果表明，网络水平的适应经验的分子机制。海马尖波/波纹（SWR）和皮层纺锤波是协调的网络振荡，提出支持记忆巩固。Quigley等人表明，KIBRA是AMPAR运输的记忆相关调节剂，是经验诱导的修饰和SWR和纺锤体的时间偶联所必需的。他们确定了可塑性机制，使网络能够适应新的经验。
Synaptic plasticity is hypothesized to underlie “replay” of salient experience during hippocampal sharp-wave/ripple (SWR)-based ensemble activity and to facilitate systems-level memory consolidation coordinated by SWRs and cortical sleep spindles. It remains unclear how molecular changes at synapses contribute to experience-induced modification of network function. The synaptic protein KIBRA regulates plasticity and memory. To determine the impact of KIBRA-regulated plasticity on circuit dynamics, we recorded in vivo neural activity from wild-type (WT) mice and littermates lacking KIBRA and examined circuit function before, during, and after novel experience. In WT mice, experience altered population activity and oscillatory dynamics in a manner consistent with incorporation of new information content in replay and enhanced hippocampal-cortical communication. While baseline SWR features were normal in KIBRA conditional knockout (cKO) mice, experience-dependent alterations in SWRs were absent. Furthermore, intra-hippocampal and hippocampal-cortical communication during SWRs was disrupted following KIBRA deletion. These results indicate molecular mechanisms that underlie network-level adaptations to experience. Hippocampal sharp wave/ripples (SWRs) and cortical spindles are coordinated network oscillations proposed to support memory consolidation. Quigley et al. show that KIBRA, a memory-associated regulator of AMPAR trafficking, is required for experience-induced modification and temporal coupling of SWRs and spindles. They identify plasticity mechanisms that enable networks to adapt to new experience.
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