Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery.
Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery.
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DOI：
10.1016/j.jconrel.2009.12.012
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发表时间：
2010-02-15
影响因子：
10.8
通讯作者：
Ziaie, Babak
中科院分区：
文献类型：
--
作者：
Siegel, Ronald A.;Gu, Yuandong;Lei, Ming;Baldi, Antonio;Nuxoll, Eric E.;Ziaie, Babak
关键词：
我们审查的努力，生产微型葡萄糖传感器和闭环胰岛素输送系统。这些器件的功能是由于葡萄糖敏感微凝胶的溶胀和收缩，这些微凝胶被整合到硅基微器件中。水凝胶的葡萄糖响应是由于并入的苯基硼酸（PBA）侧链。结果表明，在葡萄糖的存在下，这些聚合物改变其溶胀性能，无论是通过电离或通过形成葡萄糖介导的可逆交联。膨胀压力冲击微器件结构，导致微电路的谐振频率的变化或阀门动作。对未来发展和改进的潜在领域进行了描述。最后，描述了可以与葡萄糖敏感装置集成的非对称纳米微孔膜。这种膜，形成使用光刻和嵌段聚合物组装技术，可以功能化，以提高其生物相容性和溶质的大小选择性。这里描述的工作特点的相互作用的设计考虑在超分子，纳米和微米尺度。
We review efforts to produce microfabricated glucose sensors and closed loop insulin delivery systems. These devices function due to the swelling and shrinking of glucose-sensitive microgels that are incorporated into silicon-based microdevices. The glucose response of the hydrogel is due to incorporated phenylboronic acid (PBA) side chains. It is shown that in the presence of glucose, these polymers alter their swelling properties, either by ionization or by formation of glucose-mediated reversible crosslinks. Swelling pressures impinge on microdevice structures, leading either to a change in resonant frequency of a microcircuit, or valving action. Potential areas for future development and improvement are described. Finally, an asymmetric nano-microporous membrane, which may be integrated with the glucose sensitive devices, is described. This membrane, formed using photolithography and block polymer assembly techniques, can be functionalized to enhance its biocompatibility and solute size selectivity. The work described here features the interplay of design considerations at the supramolecular, nano, and micro scales.
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影响因子：
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