Optical coherence tomography angiography vessel density in children with type 1 diabetes.
Optical coherence tomography angiography vessel density in children with type 1 diabetes.
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DOI：
10.1371/journal.pone.0186479
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Hautz W
中科院分区：
文献类型：
--
作者：
Gołębiewska J;Olechowski A;Wysocka-Mincewicz M;Odrobina D;Baszyńska-Wilk M;Groszek A;Szalecki M;Hautz W
评估1型糖尿病（T1 D）儿童的光学相干断层扫描血管造影（OCTA）视网膜血管密度和中心凹无血管区（FAZ），并比较该人群与年龄匹配的健康对照组的潜在病理早期变化。该研究包括130名青春期儿童：94名T1 D（188只眼）和36名年龄匹配的对照组（60只眼）。使用AngioVue（Avanti，Optivue）进行OCTA。分析表浅丛FAZ面积（mm 2）、全表浅毛细血管密度（wsVD）、中心凹表浅血管密度（fsVD）、视网膜旁表浅血管密度（psVD）、全深血管密度（wdVD）、中心凹深血管密度（fdVD）、视网膜旁深血管密度（pdVD）、中心凹厚度（FT）（μm）、视网膜旁厚度（PFT）（μm）。在所研究的T1 D患者中，评估了关于所研究的中心凹和视网膜旁参数以及选定的潜在预测因子的相关性，即患者年龄（岁）、糖尿病持续时间（岁）、疾病发作年龄（岁）、糖化血红蛋白（HbA 1C）平均水平（%）和血清肌酐浓度（mg/dL）。两组之间的上述OCT和OCTA参数均无统计学显著差异。患者的年龄在统计学上没有显著影响任何OCT和OCTA参数。然而，HbA 1C水平升高倾向于降低动脉旁浅血管密度（p = 0.039）和动脉旁厚度（p = 0.003），血清肌酐水平升高与全深血管密度降低相关（p < 0.001）。糖尿病患者下肢深血管密度随血肌酐水平（p = 0.008）、发病年龄（p = 0.028）和糖尿病病程（p = 0.014）的增加而降低。与健康受试者相比，青春期T1 D儿童的浅表和深丛血管密度以及FAZ面积均正常。HbA 1C水平升高与psVD和PFT降低相关。需要对这些年轻患者进行纵向观察，以确定这些OCTA测量值是否可预测未来DR的严重程度。
To assess the optical coherence tomography angiography (OCTA) retinal vessel density and foveal avascular zone (FAZ) in children with type 1 diabetes (T1D) and compare potential pathologic early changes in this population to healthy age-matched controls. This study included 130 pubescent children: 94 with T1D (188 eyes) and 36 of their age-matched control group (60 eyes). OCTA was performed using AngioVue (Avanti, Optivue). FAZ area (mm2) in superficial plexus, whole superficial capillary vessel density (wsVD), fovea superficial vessel density (fsVD), parafovea superficial vessel density (psVD), whole deep vessel density (wdVD), fovea deep vessel density (fdVD), parafovea deep vessel density (pdVD), foveal thickness (FT) (μm) and parafoveal thickness (PFT) (μm) were taken into analysis. Among the studied patients with T1D there were assessed codependences regarding the investigated foveal and parafoveal parameters and selected potential predictors, i.e. patient’s age (years), diabetes duration time (years), age of onset of the disease (years), mean level of glycated hemoglobin (HbA1C) (%), and concentration of serum creatinine (mg/dL). None of the abovementioned OCT and OCTA parameters was statistically significantly different between the groups. The patient’s age statistically significantly did not influent any of the OCT and OCTA parameters. Yet an elevated level of HbA1C tended to reduce the parafovea superficial vessel density (p = 0.039), and parafoveal thickness (p = 0.003) and an increased serum creatinine level correlated with the decreased whole deep vessel density (p < 0.001). The parafovea deep vessel density in the diabetic patients decreased when the serum creatinine level (p = 0.008), age of onset of the disease (p = 0.028), and diabetes duration time (p = 0.014) rose. Vessel density, both in superficial and deep plexuses, and FAZ area are normal in pubescent children with T1D comparing to healthy subjects. An elevated level of HbA1C correlated with reduced psVD and PFT. Longitudinal observation of these young patients is needed to determine if any of these OCTA measurements are predictive of future DR severity.
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DOI：
10.1097/iae.0000000000000867
发表时间：
2015-11
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Palejwala NV;Jia Y;Gao SS;Liu L;Flaxel CJ;Hwang TS;Lauer AK;Wilson DJ;Huang D;Bailey ST
通讯作者：
Bailey ST
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
1
作者：
Matsunaga, Douglas R.;Yi, Jack J.;Kashani, Amir H.
通讯作者：
Kashani, Amir H.
DOI：
10.1097/iae.0000000000000849
发表时间：
2015-11-01
影响因子：
3.3
作者：
Takase, Noriaki;Nozaki, Miho;Ogura, Yuichiro
通讯作者：
Ogura, Yuichiro
DOI：
10.1097/iae.0000000000000859
发表时间：
2015-11-01
影响因子：
3.3
作者：
Couturier, Aude;Mane, Valerie;Tadayoni, Ramin
通讯作者：
Tadayoni, Ramin